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Ppbp pro-platelet basic protein [ Mus musculus (house mouse) ]

Gene ID: 57349, updated on 5-Mar-2024

Summary

Official Symbol
Ppbpprovided by MGI
Official Full Name
pro-platelet basic proteinprovided by MGI
Primary source
MGI:MGI:1888712
See related
Ensembl:ENSMUSG00000029372 AllianceGenome:MGI:1888712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGB; LDGF; MDGF; TGB1; CTAP3; Cxcl7; NAP-2; Scyb7; b-TG1; LA-PF4; THBGB1; CTAPIII; beta-TG; NAP-2-L1; 2400003M24Rik
Summary
Enables chemokine activity. Acts upstream of or within leukocyte migration involved in inflammatory response. Predicted to be located in platelet alpha granule. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; hemolymphoid system; and liver lobe. Orthologous to human PPBP (pro-platelet basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 131.5), liver E14.5 (RPKM 84.5) and 5 other tissues See more
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Genomic context

See Ppbp in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90916377..90917922)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90768518..90770063)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36084 Neighboring gene STARR-seq mESC enhancer starr_13603 Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene STARR-seq mESC enhancer starr_13604 Neighboring gene platelet factor 4 Neighboring gene C-X-C motif chemokine ligand 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet basic protein
Names
chemokine (C-X-C motif) ligand 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023785.3NP_076274.1  platelet basic protein precursor

    See identical proteins and their annotated locations for NP_076274.1

    Status: VALIDATED

    Source sequence(s)
    AK010273, BQ030657
    Consensus CDS
    CCDS19415.1
    UniProtKB/TrEMBL
    Q9EQI5
    Related
    ENSMUSP00000031319.7, ENSMUST00000031319.8
    Conserved Domains (1) summary
    cd00273
    Location:49111
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90916377..90917922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)