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PTGER1 prostaglandin E receptor 1 [ Homo sapiens (human) ]

Gene ID: 5731, updated on 8-Jul-2021

Summary

Official Symbol
PTGER1provided by HGNC
Official Full Name
prostaglandin E receptor 1provided by HGNC
Primary source
HGNC:HGNC:9593
See related
Ensembl:ENSG00000160951 MIM:176802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP1
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 4.8), spleen (RPKM 1.1) and 3 other tissues See more
Orthologs
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Genomic context

See PTGER1 in Genome Data Viewer
Location:
19p13.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14472466..14475354, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14583278..14586166, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DExD-box helicase 39A Neighboring gene Sharpr-MPRA regulatory region 3261 Neighboring gene protein kinase N1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene microRNA 639 Neighboring gene trans-2,3-enoyl-CoA reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP1 subtype
Names
PGE receptor, EP1 subtype
PGE2 receptor EP1 subtype
prostaglandin E receptor 1 (subtype EP1), 42kD
prostaglandin E receptor 1 (subtype EP1), 42kDa
prostaglandin E receptor 1, subtype EP1
prostanoid EP1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000955.3NP_000946.2  prostaglandin E2 receptor EP1 subtype

    See identical proteins and their annotated locations for NP_000946.2

    Status: REVIEWED

    Source sequence(s)
    BC039034, BC051286
    Consensus CDS
    CCDS12309.1
    UniProtKB/Swiss-Prot
    P34995
    Related
    ENSP00000292513.3, ENST00000292513.4
    Conserved Domains (1) summary
    pfam00001
    Location:280351
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14472466..14475354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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