U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 [ Mus musculus (house mouse) ]

Gene ID: 57296, updated on 8-Feb-2024

Summary

Official Symbol
Psmd8provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8provided by MGI
Primary source
MGI:MGI:1888669
See related
Ensembl:ENSMUSG00000030591 AllianceGenome:MGI:1888669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720456J22Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain; gonad; nose; skin; and urethra. Orthologous to human PSMD8 (proteasome 26S subunit, non-ATPase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 136.7), large intestine adult (RPKM 72.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Psmd8 in Genome Data Viewer
Location:
7 B1; 7 16.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28873612..28880098, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29174187..29180673, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sprouty-related EVH1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene gametogenetin Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene cation channel sperm associated auxiliary subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E10433 Neighboring gene STARR-positive B cell enhancer ABC_E4913 Neighboring gene STARR-seq mESC enhancer starr_18461 Neighboring gene potassium inwardly-rectifying channel, subfamily K, member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome regulatory particle IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
26S proteasome non-ATPase regulatory subunit 8
Names
26S proteasome regulatory subunit RPN12
26S proteasome regulatory subunit S14
proteasome 26S non-ATPase subunit 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026545.3NP_080821.3  26S proteasome non-ATPase regulatory subunit 8

    See identical proteins and their annotated locations for NP_080821.3

    Status: VALIDATED

    Source sequence(s)
    AK003436, CD774979, CF732286
    Consensus CDS
    CCDS52169.1
    UniProtKB/Swiss-Prot
    Q9CX56
    UniProtKB/TrEMBL
    Q3TVY0
    Related
    ENSMUSP00000139514.2, ENSMUST00000186182.2
    Conserved Domains (1) summary
    pfam10075
    Location:204318
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28873612..28880098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)