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TAS2R38 taste 2 receptor member 38 [ Homo sapiens (human) ]

Gene ID: 5726, updated on 22-Aug-2020

Summary

Official Symbol
TAS2R38provided by HGNC
Official Full Name
taste 2 receptor member 38provided by HGNC
Primary source
HGNC:HGNC:9584
See related
Ensembl:ENSG00000257138 MIM:607751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC; T2R38; T2R61; THIOT
Summary
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Orthologs

Genomic context

See TAS2R38 in Genome Data Viewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141972631..141973773, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141672431..141673573, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily A member 4 Neighboring gene C-type lectin domain containing 5A Neighboring gene maltase-glucoamylase Neighboring gene maltase-glucoamylase 2 (putative)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
GeneReviews: Not available
The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12.
GeneReviews: Not available
Thiourea tasting
MedGen: C1868397 OMIM: 171200 GeneReviews: Not available
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General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 38
Names
PTC bitter taste receptor
taste receptor type 2 member 61
taste receptor, type 2, member 38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016141.1 RefSeqGene

    Range
    5001..6143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176817.5NP_789787.5  taste receptor type 2 member 38

    Status: REVIEWED

    Source sequence(s)
    AC073647
    Consensus CDS
    CCDS34765.1
    Related
    ENSP00000448219.1, ENST00000547270.1
    Conserved Domains (1) summary
    cd15025
    Location:16309
    7tm_TAS2R38; mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141972631..141973773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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