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LYZL6 lysozyme like 6 [ Homo sapiens (human) ]

Gene ID: 57151, updated on 23-Nov-2021

Summary

Official Symbol
LYZL6provided by HGNC
Official Full Name
lysozyme like 6provided by HGNC
Primary source
HGNC:HGNC:29614
See related
Ensembl:ENSG00000275722 MIM:612751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYC1; LYZB; UNQ754; PRO1485; TKAL754; HEL-S-6a
Summary
This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Restricted expression toward testis (RPKM 15.7) See more
Orthologs
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Genomic context

See LYZL6 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35934518..35943713, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34261522..34270717, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37, member A3 pseudogene Neighboring gene RAD52 motif containing 1 Neighboring gene Sharpr-MPRA regulatory region 10414 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sperm plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysozyme-like protein 6
Names
epididymis secretory sperm binding protein Li 6a
lysozyme B
lysozyme homolog
NP_001186880.1
NP_065159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199951.3NP_001186880.1  lysozyme-like protein 6 precursor

    See identical proteins and their annotated locations for NP_001186880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244100, AY742214, BC054481, BE550275, DB462957, HY024713
    Consensus CDS
    CCDS11302.1
    UniProtKB/Swiss-Prot
    O75951
    UniProtKB/TrEMBL
    A0A080YUZ6
    Related
    ENSP00000482955.1, ENST00000618542.4
    Conserved Domains (1) summary
    cd00119
    Location:22142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  2. NM_020426.4NP_065159.1  lysozyme-like protein 6 precursor

    See identical proteins and their annotated locations for NP_065159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244100, AY742214, BC054481, BE550275, DB462957, HY024713
    Consensus CDS
    CCDS11302.1
    UniProtKB/Swiss-Prot
    O75951
    UniProtKB/TrEMBL
    A0A080YUZ6
    Related
    ENSP00000483897.1, ENST00000615905.5
    Conserved Domains (1) summary
    cd00119
    Location:22142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35934518..35943713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    169050..178245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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