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PAK5 p21 (RAC1) activated kinase 5 [ Homo sapiens (human) ]

Gene ID: 57144, updated on 12-Aug-2018

Summary

Official Symbol
PAK5provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 5provided by HGNC
Primary source
HGNC:HGNC:15916
See related
Ensembl:ENSG00000101349 MIM:608038; Vega:OTTHUMG00000031857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAK7
Summary
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue See more
Orthologs

Genomic context

See PAK5 in Genome Data Viewer
Location:
20p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (9537390..9839042, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9518037..9819687, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 4 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene uncharacterized LOC105372523 Neighboring gene uncharacterized LOC101929348 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene SNAP25 antisense RNA 1 Neighboring gene PPARG activating RBM14 associated lncRNA 1 Neighboring gene ankyrin repeat and EF-hand domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Activation of Rac, organism-specific biosystem (from REACTOME)
    Activation of Rac, organism-specific biosystemA low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion.
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Renal cell carcinoma, organism-specific biosystem (from KEGG)
    Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Renal cell carcinoma, conserved biosystem (from KEGG)
    Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1264, MGC26232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell migration TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 5
Names
PAK-5
PAK-7
p21 (RAC1) activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
p21(CDKN1A)-activated kinase 7
p21-activated kinase 5
p21-activated kinase 7
p21CDKN1A-activated kinase 7
protein kinase PAK5
serine/threonine-protein kinase PAK 7
serine/threonine-protein kinase PAK7
NP_065074.1
NP_817127.1
XP_016883449.1
XP_016883450.1
XP_016883451.1
XP_016883452.1
XP_016883453.1
XP_016883454.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020341.3NP_065074.1  serine/threonine-protein kinase PAK 5

    See identical proteins and their annotated locations for NP_065074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.
    Source sequence(s)
    AB033090, AB040812, AK315820
    Consensus CDS
    CCDS13107.1
    UniProtKB/Swiss-Prot
    Q9P286
    UniProtKB/TrEMBL
    B0AZM9
    Related
    ENSP00000367686.3, OTTHUMP00000030258, ENST00000378429.3, OTTHUMT00000077962
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_177990.2NP_817127.1  serine/threonine-protein kinase PAK 5

    See identical proteins and their annotated locations for NP_817127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB040812, AK307926, AK315820
    Consensus CDS
    CCDS13107.1
    UniProtKB/Swiss-Prot
    Q9P286
    UniProtKB/TrEMBL
    B0AZM9
    Related
    ENSP00000322957.5, OTTHUMP00000030259, ENST00000353224.9, OTTHUMT00000077963
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    9537390..9839042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027960.1XP_016883449.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. XM_017027961.1XP_016883450.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  3. XM_017027962.1XP_016883451.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  4. XM_017027964.1XP_016883453.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  5. XM_017027965.1XP_016883454.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  6. XM_017027963.1XP_016883452.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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