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PAK5 p21 (RAC1) activated kinase 5 [ Homo sapiens (human) ]

Gene ID: 57144, updated on 5-Sep-2021

Summary

Official Symbol
PAK5provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 5provided by HGNC
Primary source
HGNC:HGNC:15916
See related
Ensembl:ENSG00000101349 MIM:608038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAK7
Summary
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue See more
Orthologs
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Genomic context

See PAK5 in Genome Data Viewer
Location:
20p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (9537370..9839076, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9518017..9819724, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene phospholipase C beta 4 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene uncharacterized LOC105372523 Neighboring gene uncharacterized LOC101929348 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene SNAP25 antisense RNA 1 Neighboring gene PPARG activating RBM14 associated lncRNA 1 Neighboring gene ankyrin repeat and EF-hand domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1264, MGC26232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 5
Names
PAK-5
PAK-7
p21 (RAC1) activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
p21(CDKN1A)-activated kinase 7
p21-activated kinase 5
p21-activated kinase 7
p21CDKN1A-activated kinase 7
protein kinase PAK5
serine/threonine-protein kinase PAK 7
serine/threonine-protein kinase PAK7
NP_065074.1
NP_817127.1
XP_016883449.1
XP_016883450.1
XP_016883451.1
XP_016883452.1
XP_016883453.1
XP_016883454.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020341.5NP_065074.1  serine/threonine-protein kinase PAK 5

    See identical proteins and their annotated locations for NP_065074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.
    Source sequence(s)
    AB033090, AB040812, AK315820, AL031652, AL034427
    Consensus CDS
    CCDS13107.1
    UniProtKB/Swiss-Prot
    Q9P286
    UniProtKB/TrEMBL
    B0AZM9
    Related
    ENSP00000367686.3, ENST00000378429.3
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_177990.4NP_817127.1  serine/threonine-protein kinase PAK 5

    See identical proteins and their annotated locations for NP_817127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB040812, AK307926, AK315820, AL031652, AL034427
    Consensus CDS
    CCDS13107.1
    UniProtKB/Swiss-Prot
    Q9P286
    UniProtKB/TrEMBL
    B0AZM9
    Related
    ENSP00000322957.5, ENST00000353224.10
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    9537370..9839076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027960.1XP_016883449.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. XM_017027961.1XP_016883450.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  3. XM_017027962.1XP_016883451.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  4. XM_017027964.1XP_016883453.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  5. XM_017027965.1XP_016883454.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  6. XM_017027963.1XP_016883452.1  serine/threonine-protein kinase PAK 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9P286
    Conserved Domains (3) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    smart00220
    Location:454700
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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