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TIGAR TP53 induced glycolysis regulatory phosphatase [ Homo sapiens (human) ]

Gene ID: 57103, updated on 4-Nov-2018

Summary

Official Symbol
TIGARprovided by HGNC
Official Full Name
TP53 induced glycolysis regulatory phosphataseprovided by HGNC
Primary source
HGNC:HGNC:1185
See related
Ensembl:ENSG00000078237 MIM:610775; Vega:OTTHUMG00000168124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FR2BP; C12orf5
Summary
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 2.3), colon (RPKM 2.2) and 24 other tissues See more
Orthologs

Genomic context

See TIGAR in Genome Data Viewer
Location:
12p13.32
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (4321193..4360028)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4430359..4469194)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369612 Neighboring gene CCND2 antisense RNA 1 Neighboring gene cyclin D2 Neighboring gene ribosomal protein S15 pseudogene 7 Neighboring gene fibroblast growth factor 23 Neighboring gene fibroblast growth factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
    Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
    Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Fructose and mannose metabolism, organism-specific biosystem (from KEGG)
    Fructose and mannose metabolism, organism-specific biosystem
    Fructose and mannose metabolism
  • Fructose and mannose metabolism, conserved biosystem (from KEGG)
    Fructose and mannose metabolism, conserved biosystem
    Fructose and mannose metabolism
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • fructose 2,6-bisphosphate biosynthesis, conserved biosystem (from BIOCYC)
    fructose 2,6-bisphosphate biosynthesis, conserved biosystemGeneral Background |FRAME: CPD-535 "Fructose-2,6-bisphosphate"| is a potent allosteric regulator with dual simultaneous functions. It is an activator of |FRAME: HS06881-MONOMER "phosphofructokinase"...
  • fructose 2,6-bisphosphate synthesis, organism-specific biosystem (from BIOCYC)
    fructose 2,6-bisphosphate synthesis, organism-specific biosystemGeneral Background : CPD-535 is a potent allosteric regulator with dual simultaneous functions. It is an activator of : HS06881-MONOMER "phosphofructokinase" and an inhibitor of : CPLX66-505 "fructo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bisphosphoglycerate 2-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
fructose-2,6-bisphosphate 2-phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
fructose-2,6-bisphosphate 2-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cobalt ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
fructose 1,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fructose 2,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intestinal epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucose catabolic process to lactate via pyruvate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fructose-2,6-bisphosphatase TIGAR
Names
TP53-induced glycolysis and apoptosis regulator
fructose-2,6-bisphosphate 2-phosphatase
probable fructose-2,6-bisphosphatase TIGAR
transactivated by NS3TP2 protein
NP_065108.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020375.2NP_065108.1  fructose-2,6-bisphosphatase TIGAR

    See identical proteins and their annotated locations for NP_065108.1

    Status: REVIEWED

    Source sequence(s)
    AC008012, AJ272206, BX098281, DB480618
    Consensus CDS
    CCDS8525.1
    UniProtKB/Swiss-Prot
    Q9NQ88
    Related
    ENSP00000179259.4, OTTHUMP00000237991, ENST00000179259.5, OTTHUMT00000398290
    Conserved Domains (1) summary
    pfam00300
    Location:6210
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    4321193..4360028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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