Format

Send to:

Choose Destination

AVEN apoptosis and caspase activation inhibitor [ Homo sapiens (human) ]

Gene ID: 57099, updated on 1-Jun-2020

Summary

Official Symbol
AVENprovided by HGNC
Official Full Name
apoptosis and caspase activation inhibitorprovided by HGNC
Primary source
HGNC:HGNC:13509
See related
Ensembl:ENSG00000169857 MIM:605265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDCD12
Expression
Ubiquitous expression in testis (RPKM 1.9), placenta (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See AVEN in Genome Data Viewer
Location:
15q14
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (33851785..34074877, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34158428..34331303, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928134 Neighboring gene ryanodine receptor 3 Neighboring gene complement C1q binding protein pseudogene 3 Neighboring gene cholinergic receptor muscarinic 5 Neighboring gene uncharacterized LOC107984748 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene ER membrane protein complex subunit 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell death regulator Aven
Names
apoptosis, caspase activation inhibitor
programmed cell death 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020371.3NP_065104.1  cell death regulator Aven

    See identical proteins and their annotated locations for NP_065104.1

    Status: VALIDATED

    Source sequence(s)
    AC069045, BC010488, BC063533, BU855198
    Consensus CDS
    CCDS10030.1
    UniProtKB/Swiss-Prot
    Q9NQS1
    Related
    ENSP00000306822.3, ENST00000306730.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    33851785..34074877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521818.2XP_011520120.1  cell death regulator Aven isoform X1

  2. XM_024449999.1XP_024305767.1  cell death regulator Aven isoform X2

  3. XM_011521819.2XP_011520121.1  cell death regulator Aven isoform X2

  4. XM_011521820.1XP_011520122.1  cell death regulator Aven isoform X3

RNA

  1. XR_002957666.1 RNA Sequence

  2. XR_002957667.1 RNA Sequence

  3. XR_001751364.2 RNA Sequence

Support Center