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TRIM49 tripartite motif containing 49 [ Homo sapiens (human) ]

Gene ID: 57093, updated on 11-Jun-2021

Summary

Official Symbol
TRIM49provided by HGNC
Official Full Name
tripartite motif containing 49provided by HGNC
Primary source
HGNC:HGNC:13431
See related
Ensembl:ENSG00000168930 MIM:606124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF18; TRIM49A; TRIM49L2
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]
Expression
Low expression observed in reference dataset See more
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Genomic context

See TRIM49 in Genome Data Viewer
Location:
11q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (89766436..89808575, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89530823..89541743, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene UBTF like 2 (pseudogene) Neighboring gene tripartite motif containing 64D, pseudogene Neighboring gene ankyrin repeat domain 33B pseudogene Neighboring gene tripartite motif containing 64B pseudogene Neighboring gene tripartite motif containing 53B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 49
Names
ring finger protein 18
testis-specific RING Finger protein
testis-specific ring-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020358.2NP_065091.1  tripartite motif-containing protein 49

    See identical proteins and their annotated locations for NP_065091.1

    Status: REVIEWED

    Source sequence(s)
    AP004833
    Consensus CDS
    CCDS8287.1
    UniProtKB/Swiss-Prot
    P0CI25
    Related
    ENSP00000327604.1, ENST00000329758.5
    Conserved Domains (2) summary
    cd16603
    Location:1257
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285448
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    89766436..89808575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448617.1XP_024304385.1  tripartite motif-containing protein 49 isoform X1

    Conserved Domains (2) summary
    cd16603
    Location:1257
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285441
    SPRY; SPRY domain
  2. XM_017018027.2XP_016873516.1  tripartite motif-containing protein 49 isoform X2

    UniProtKB/TrEMBL
    E9PK69
    Related
    ENSP00000431618.2, ENST00000532501.2
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