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AGTRAP angiotensin II receptor associated protein [ Homo sapiens (human) ]

Gene ID: 57085, updated on 7-Oct-2018

Summary

Official Symbol
AGTRAPprovided by HGNC
Official Full Name
angiotensin II receptor associated proteinprovided by HGNC
Primary source
HGNC:HGNC:13539
See related
Ensembl:ENSG00000177674 MIM:608729; Vega:OTTHUMG00000002230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATRAP
Summary
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues See more
Orthologs

Genomic context

See AGTRAP in Genome Data Viewer
Location:
1p36.22
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11736085..11750771)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11796142..11810828)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F-box protein 6 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167 Neighboring gene uncharacterized LOC102724659

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29646

Gene Ontology Provided by GOA

Function Evidence Code Pubs
angiotensin type II receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
type-1 angiotensin II receptor-associated protein
Names
AT1 receptor-associated protein
ATI receptor-associated protein
angiotensin II, type I receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040194.1NP_001035284.1  type-1 angiotensin II receptor-associated protein isoform b

    See identical proteins and their annotated locations for NP_001035284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BI117521, BQ672962, CA866314
    Consensus CDS
    CCDS30585.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000365816.4, OTTHUMP00000002270, ENST00000376629.8, OTTHUMT00000006336
    Conserved Domains (1) summary
    pfam06396
    Location:9145
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
  2. NM_001040195.1NP_001035285.1  type-1 angiotensin II receptor-associated protein isoform c

    See identical proteins and their annotated locations for NP_001035285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform c) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BI117521, BQ672962, CA866314
    Consensus CDS
    CCDS30586.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000365824.3, OTTHUMP00000002271, ENST00000376637.7, OTTHUMT00000006337
  3. NM_001040196.1NP_001035286.1  type-1 angiotensin II receptor-associated protein isoform d

    See identical proteins and their annotated locations for NP_001035286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform d) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BE782705, BI117521, BQ672962, CA866314
    Consensus CDS
    CCDS44056.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000408505.2, OTTHUMP00000221110, ENST00000452018.6, OTTHUMT00000366955
    Conserved Domains (1) summary
    cl05741
    Location:120
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
  4. NM_001040197.1NP_001035287.1  type-1 angiotensin II receptor-associated protein isoform e

    See identical proteins and their annotated locations for NP_001035287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform e) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI741916, BC017328, BE782705, BI117521, BQ672962, CA866314, CD674964
    Consensus CDS
    CCDS41248.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000383688.2, OTTHUMP00000221109, ENST00000400895.6, OTTHUMT00000366954
    Conserved Domains (1) summary
    cl05741
    Location:120
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
  5. NM_020350.4NP_065083.3  type-1 angiotensin II receptor-associated protein isoform a

    See identical proteins and their annotated locations for NP_065083.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the most common transcript and encodes isoform a.
    Source sequence(s)
    AF312374, AI741916, BC017328, BI117521, BQ672962, CA866314
    Consensus CDS
    CCDS136.1
    UniProtKB/Swiss-Prot
    Q6RW13
    Related
    ENSP00000319713.5, OTTHUMP00000002269, ENST00000314340.9, OTTHUMT00000006335
    Conserved Domains (1) summary
    pfam06396
    Location:9152
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    11736085..11750771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541802.2XP_011540104.1  type-1 angiotensin II receptor-associated protein isoform X2

    Related
    ENSP00000365814.1, OTTHUMP00000002272, ENST00000376627.6
  2. XM_011541800.3XP_011540102.1  type-1 angiotensin II receptor-associated protein isoform X1

    Conserved Domains (1) summary
    pfam06396
    Location:22164
    AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
  3. XM_011541799.3XP_011540101.2  type-1 angiotensin II receptor-associated protein isoform X3

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