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Pdxp pyridoxal (pyridoxine, vitamin B6) phosphatase [ Mus musculus (house mouse) ]

Gene ID: 57028, updated on 9-May-2024

Summary

Official Symbol
Pdxpprovided by MGI
Official Full Name
pyridoxal (pyridoxine, vitamin B6) phosphataseprovided by MGI
Primary source
MGI:MGI:1919282
See related
Ensembl:ENSMUSG00000116165 AllianceGenome:MGI:1919282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLPP; 1600027H05Rik
Summary
Enables magnesium ion binding activity; protein homodimerization activity; and pyridoxal phosphatase activity. Involved in dephosphorylation and pyridoxal phosphate catabolic process. Located in cell-cell junction. Is expressed in alimentary system; eye; limb; nervous system; and tail. Orthologous to human PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 56.1), frontal lobe adult (RPKM 56.0) and 17 other tissues See more
Orthologs
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Genomic context

See Pdxp in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78796342..78803717)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78912160..78919517)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene microRNA 6955 Neighboring gene STARR-seq mESC enhancer starr_39162 Neighboring gene SH3-domain binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E480 Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene nucleolar protein 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyridoxal phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with contractile ring ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with midbody ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chronophin
Names
PLP phosphatase
PLP-phosophatase
chronophilin
pyridoxal 5'-phosphate phosphatase
pyridoxal phosphate phosphatase
NP_064667.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020271.3NP_064667.2  chronophin

    See identical proteins and their annotated locations for NP_064667.2

    Status: VALIDATED

    Source sequence(s)
    AI845716, BC069982, CX236940
    Consensus CDS
    CCDS27627.1
    UniProtKB/Swiss-Prot
    P60487
    Related
    ENSMUSP00000086796.5, ENSMUST00000089378.5
    Conserved Domains (3) summary
    TIGR01452
    Location:18286
    PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family
    pfam13242
    Location:206286
    Hydrolase_like; HAD-hyrolase-like
    pfam13344
    Location:22128
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78796342..78803717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003951417.2 RNA Sequence