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CHPT1 choline phosphotransferase 1 [ Homo sapiens (human) ]

Gene ID: 56994, updated on 1-Jun-2020

Summary

Official Symbol
CHPT1provided by HGNC
Official Full Name
choline phosphotransferase 1provided by HGNC
Primary source
HGNC:HGNC:17852
See related
Ensembl:ENSG00000111666 MIM:616747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPT; CPT1
Expression
Ubiquitous expression in testis (RPKM 11.8), duodenum (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See CHPT1 in Genome Data Viewer
Location:
12q23.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (101697640..101752038)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102091417..102122852)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369938 Neighboring gene myosin binding protein C1 Neighboring gene uncharacterized LOC105369937 Neighboring gene RNY1 pseudogene 16 Neighboring gene synaptonemal complex protein 3 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunits alpha and beta Neighboring gene RNA, U6 small nuclear 101, pseudogene Neighboring gene ST13, Hsp70 interacting protein pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
diacylglycerol binding NAS
Non-traceable Author Statement
more info
PubMed 
diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol cholinephosphotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphotransferase activity, for other substituted phosphate groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CDP-choline pathway NAS
Non-traceable Author Statement
more info
PubMed 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
platelet activating factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle NAS
Non-traceable Author Statement
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cholinephosphotransferase 1
Names
AAPT1-like protein
cholinephosphotransferase 1 alpha
diacylglycerol cholinephosphotransferase 1
hCPT1
phosphatidylcholine synthesizing enzyme
NP_064629.2
XP_011536876.1
XP_011536877.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020244.3NP_064629.2  cholinephosphotransferase 1

    See identical proteins and their annotated locations for NP_064629.2

    Status: VALIDATED

    Source sequence(s)
    AC063950, BC050429, CD300296
    Consensus CDS
    CCDS9086.1
    UniProtKB/Swiss-Prot
    Q8WUD6
    Related
    ENSP00000229266.3, ENST00000229266.8
    Conserved Domains (1) summary
    cl00453
    Location:25337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    101697640..101752038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538574.1XP_011536876.1  cholinephosphotransferase 1 isoform X1

    Conserved Domains (1) summary
    cl00453
    Location:25213
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  2. XM_011538575.1XP_011536877.1  cholinephosphotransferase 1 isoform X2

RNA

  1. XR_001748817.1 RNA Sequence

  2. XR_001748816.1 RNA Sequence

  3. XR_001748818.1 RNA Sequence

  4. XR_245946.2 RNA Sequence

    Related
    ENST00000552351.5
  5. XR_002957362.1 RNA Sequence

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