Format

Send to:

Choose Destination

TCIM transcriptional and immune response regulator [ Homo sapiens (human) ]

Gene ID: 56892, updated on 8-Dec-2018

Summary

Official Symbol
TCIMprovided by HGNC
Official Full Name
transcriptional and immune response regulatorprovided by HGNC
Primary source
HGNC:HGNC:1357
See related
Ensembl:ENSG00000176907 MIM:607702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TC1; TC-1; C8orf4
Summary
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Orthologs

Genomic context

See TCIM in Genome Data Viewer
Location:
8p11.21
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (40153468..40155308)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (40010987..40012827)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 150 Neighboring gene uncharacterized LOC105379385 Neighboring gene uncharacterized LOC105379386 Neighboring gene HNF1 motif-containing MPRA enhancer 269 Neighboring gene SIRT1 regulating lncRNA tumor promoter

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
transcriptional and immune response regulator
Names
human thyroid cancer 1
protein C8orf4
thyroid cancer protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020130.4NP_064515.1  transcriptional and immune response regulator

    See identical proteins and their annotated locations for NP_064515.1

    Status: REVIEWED

    Source sequence(s)
    AI861861, AI935347, BC021672, BX434108
    Consensus CDS
    CCDS6115.1
    UniProtKB/Swiss-Prot
    Q9NR00
    Related
    ENSP00000319914.3, ENST00000315792.4
    Conserved Domains (1) summary
    pfam15063
    Location:1184
    TC1; Thyroid cancer protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    40153468..40155308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center