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TCEAL7 transcription elongation factor A like 7 [ Homo sapiens (human) ]

Gene ID: 56849, updated on 10-Oct-2023

Summary

Official Symbol
TCEAL7provided by HGNC
Official Full Name
transcription elongation factor A like 7provided by HGNC
Primary source
HGNC:HGNC:28336
See related
Ensembl:ENSG00000182916 MIM:300771; AllianceGenome:HGNC:28336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX5
Summary
Predicted to enable WW domain binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 45.0), endometrium (RPKM 18.0) and 11 other tissues See more
Orthologs
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Genomic context

See TCEAL7 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103330239..103332326)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101777239..101779326)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102585167..102587254)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20920 Neighboring gene brain expressed X-linked 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102585683-102586182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102603213-102603753 Neighboring gene uncharacterized LOC124905204 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:102610887-102612086 Neighboring gene transcription elongation factor A like 9 Neighboring gene brain expressed X-linked 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
transcription elongation factor A protein-like 7
Names
TCEA-like protein 7
transcription elongation factor A (SII)-like 7
transcription elongation factor S-II protein-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348258.2NP_001335187.1  transcription elongation factor A protein-like 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI753521, BC016786, BQ878422
    Consensus CDS
    CCDS14506.1
    UniProtKB/Swiss-Prot
    B3KSV2, Q96AT4, Q9BRU2
    Related
    ENSP00000361751.1, ENST00000372666.1
    Conserved Domains (1) summary
    pfam04538
    Location:1100
    BEX; Brain expressed X-linked like family
  2. NM_152278.5NP_689491.1  transcription elongation factor A protein-like 7

    See identical proteins and their annotated locations for NP_689491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI753521, BC016786, DA142141, DB481725
    Consensus CDS
    CCDS14506.1
    UniProtKB/Swiss-Prot
    B3KSV2, Q96AT4, Q9BRU2
    Related
    ENSP00000329794.4, ENST00000332431.5
    Conserved Domains (1) summary
    pfam04538
    Location:1100
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103330239..103332326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101777239..101779326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)