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TCEAL7 transcription elongation factor A like 7 [ Homo sapiens (human) ]

Gene ID: 56849, updated on 2-Nov-2024

Summary

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Official Symbol
TCEAL7provided by HGNC
Official Full Name
transcription elongation factor A like 7provided by HGNC
Primary source
HGNC:HGNC:28336
See related
Ensembl:ENSG00000182916 MIM:300771; AllianceGenome:HGNC:28336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX5
Summary
Involved in negative regulation of DNA-templated transcription and negative regulation of NF-kappaB transcription factor activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 45.0), endometrium (RPKM 18.0) and 11 other tissues See more
Orthologs
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Genomic context

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See TCEAL7 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103330239..103332326)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101777239..101779326)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102585167..102587254)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20920 Neighboring gene brain expressed X-linked 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102585683-102586182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102603213-102603753 Neighboring gene uncharacterized LOC124905204 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:102610887-102612086 Neighboring gene transcription elongation factor A like 9 Neighboring gene brain expressed X-linked 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis. Huang CY, et al. PLoS One, 2013. PMID 23372750, Free PMC Article
  2. Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. Peedicayil A, et al. Gynecol Oncol, 2009 Aug. PMID 19419758, Free PMC Article
  3. Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Chien J, et al. Oncogene, 2005 Jul 28. PMID 15870691
  4. Hypoxic Glioma Cell-Secreted Exosomal miR-301a Activates Wnt/β-catenin Signaling and Promotes Radiation Resistance by Targeting TCEAL7. Yue X, et al. Mol Ther, 2019 Nov 6. PMID 31402274, Free PMC Article
  5. Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer. Orhan C, et al. Mol Biol Rep, 2019 Oct. PMID 31321645

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
    Title: Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
  2. These results suggest that miR-301a promotes radiation resistance by repressing anti-oncogene TCEAL7 expression and then activity of the Wnt/beta-catenin-signaling pathway.
    Title: Hypoxic Glioma Cell-Secreted Exosomal miR-301a Activates Wnt/β-catenin Signaling and Promotes Radiation Resistance by Targeting TCEAL7.
  3. Findings show that TCEAL7 expression is down-regulated in non-small cell lung cancer (NSCLC) like in other human cancers. This down-regulation was also associated with CCND1 over-expression in lung tumors.
    Title: Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
  4. Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis.
    Title: Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.
  5. alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression
    Title: TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.
  6. TCEAL7 in the negative regulation of NF-kappaB signaling at the basal level by modulating transcriptional activity of NF-kappaB on its target gene promoters in ovarian cells.
    Title: TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway.
  7. TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers.
    Title: Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
  9. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation is reported.
    Title: A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.
  10. TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor.
    Title: Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC23947, MPMGp800C04260Q003

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription elongation factor A protein-like 7
Names
TCEA-like protein 7
transcription elongation factor A (SII)-like 7
transcription elongation factor S-II protein-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348258.2 → NP_001335187.1  transcription elongation factor A protein-like 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI753521, BC016786, BQ878422
    Consensus CDS
    CCDS14506.1
    UniProtKB/Swiss-Prot
    B3KSV2, Q96AT4, Q9BRU2
    Related
    ENSP00000361751.1, ENST00000372666.1
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 100
    BEX; Brain expressed X-linked like family

  2. NM_152278.5 → NP_689491.1  transcription elongation factor A protein-like 7

    See identical proteins and their annotated locations for NP_689491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI753521, BC016786, DA142141, DB481725
    Consensus CDS
    CCDS14506.1
    UniProtKB/Swiss-Prot
    B3KSV2, Q96AT4, Q9BRU2
    Related
    ENSP00000329794.4, ENST00000332431.5
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 100
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103330239..103332326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101777239..101779326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRU2.2 GenPept UniProtKB/Swiss-Prot:Q9BRU2

Gene LinkOut

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