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Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 [ Mus musculus (house mouse) ]

Gene ID: 56847, updated on 27-Feb-2024

Summary

Official Symbol
Aldh1a3provided by MGI
Official Full Name
aldehyde dehydrogenase family 1, subfamily A3provided by MGI
Primary source
MGI:MGI:1861722
See related
Ensembl:ENSMUSG00000015134 AllianceGenome:MGI:1861722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V1; ALDH6; RALDH3
Summary
Enables NAD+ binding activity; aldehyde dehydrogenase (NAD+) activity; and thyroid hormone binding activity. Involved in Harderian gland development; embryonic camera-type eye development; and nose development. Acts upstream of or within several processes, including nucleus accumbens development; righting reflex; and sensory organ development. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 9.8), bladder adult (RPKM 6.2) and 17 other tissues See more
Orthologs
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Genomic context

See Aldh1a3 in Genome Data Viewer
Location:
7 C; 7 35.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66040640..66077225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66390892..66427477, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat kinase 1 Neighboring gene predicted gene, 45989 Neighboring gene STARR-seq mESC enhancer starr_19084 Neighboring gene STARR-positive B cell enhancer ABC_E3724 Neighboring gene STARR-positive B cell enhancer ABC_E10441 Neighboring gene microRNA 7057 Neighboring gene predicted gene, 33515 Neighboring gene STARR-seq mESC enhancer starr_19085 Neighboring gene predicted gene, 53392

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Harderian gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nose development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleus accumbens development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory pit development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinoic acid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within righting reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinaldehyde dehydrogenase 3
Names
RALDH-3
aldehyde dehydrogenase family 1 member A3
aldehyde dehydrogenase-6
NP_444310.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053080.3NP_444310.3  retinaldehyde dehydrogenase 3

    See identical proteins and their annotated locations for NP_444310.3

    Status: VALIDATED

    Source sequence(s)
    AK147006, BC038646
    Consensus CDS
    CCDS21345.1
    UniProtKB/Swiss-Prot
    Q9EQP7, Q9JHW9, Q9JI72
    UniProtKB/TrEMBL
    Q3UIA4
    Related
    ENSMUSP00000015278.8, ENSMUST00000015278.15
    Conserved Domains (1) summary
    cd07141
    Location:26506
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    66040640..66077225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)