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IFNK interferon kappa [ Homo sapiens (human) ]

Gene ID: 56832, updated on 11-Jun-2021

Summary

Official Symbol
IFNKprovided by HGNC
Official Full Name
interferon kappaprovided by HGNC
Primary source
HGNC:HGNC:21714
See related
Ensembl:ENSG00000147896 MIM:615326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFNT1; INFE1
Summary
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IFNK in Genome Data Viewer
Location:
9p21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (27524290..27526498)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27524288..27526496)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene equatorin Neighboring gene MOB kinase activator 3B Neighboring gene uncharacterized LOC105376001 Neighboring gene uncharacterized LOC112268043 Neighboring gene uncharacterized LOC107987057 Neighboring gene C9orf72-SMCR8 complex subunit Neighboring gene chromosome 9 open reading frame 72 repeat instability region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
GeneReviews: Not available
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
GeneReviews: Not available
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
GeneReviews: Not available
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I interferon receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IC
Inferred by Curator
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon kappa
Names
IFN-kappa
interferon-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020124.3NP_064509.2  interferon kappa precursor

    See identical proteins and their annotated locations for NP_064509.2

    Status: REVIEWED

    Source sequence(s)
    AL451123
    Consensus CDS
    CCDS6521.1
    UniProtKB/Swiss-Prot
    Q9P0W0
    Related
    ENSP00000276943.2, ENST00000276943.3
    Conserved Domains (1) summary
    pfam00143
    Location:38197
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    27524290..27526498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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