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Hacl1 2-hydroxyacyl-CoA lyase 1 [ Mus musculus (house mouse) ]

Gene ID: 56794, updated on 26-Sep-2022

Summary

Official Symbol
Hacl1provided by MGI
Official Full Name
2-hydroxyacyl-CoA lyase 1provided by MGI
Primary source
MGI:MGI:1929657
See related
Ensembl:ENSMUSG00000021884 AllianceGenome:MGI:1929657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpcl; Phyh2; 1600020H07Rik
Summary
Enables carbon-carbon lyase activity. Involved in fatty acid alpha-oxidation. Acts upstream of or within lipid metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 112.3), liver E18 (RPKM 83.8) and 2 other tissues See more
Orthologs
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Genomic context

See Hacl1 in Genome Data Viewer
Location:
14; 14 B
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31329183..31364201, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31607226..31640965, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC102639719 Neighboring gene biotinidase Neighboring gene predicted gene, 53840 Neighboring gene ankyrin repeat domain 28 Neighboring gene predicted gene, 36164

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-hydroxy-3-methylhexadecanoyl-CoA lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables 2-hydroxyacyl-CoA lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables carbon-carbon lyase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbon-carbon lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiamine pyrophosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid alpha-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid alpha-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in methyl-branched fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phytanic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
2-hydroxyacyl-CoA lyase 1
Names
2-HPCL
2-hydroxyphytanoyl-CoA lyase
phytanoyl-CoA 2-hydroxylase 2
NP_064359.2
XP_036014660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019975.3NP_064359.2  2-hydroxyacyl-CoA lyase 1

    See identical proteins and their annotated locations for NP_064359.2

    Status: VALIDATED

    Source sequence(s)
    AK041686, BY340097
    Consensus CDS
    CCDS26915.1
    UniProtKB/Swiss-Prot
    Q9DAV1, Q9QXE0
    Related
    ENSMUSP00000022437.9, ENSMUST00000022437.16
    Conserved Domains (4) summary
    cd07035
    Location:22175
    TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
    PRK09259
    Location:19564
    PRK09259; putative oxalyl-CoA decarboxylase; Validated
    cd02004
    Location:380563
    TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
    pfam00205
    Location:208335
    TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31329183..31364201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158767.1XP_036014660.1  2-hydroxyacyl-CoA lyase 1 isoform X1

    Conserved Domains (1) summary
    PRK09259
    Location:19555
    PRK09259; putative oxalyl-CoA decarboxylase; Validated