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PSG9 pregnancy specific beta-1-glycoprotein 9 [ Homo sapiens (human) ]

Gene ID: 5678, updated on 25-Jan-2022

Summary

Official Symbol
PSG9provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 9provided by HGNC
Primary source
HGNC:HGNC:9526
See related
Ensembl:ENSG00000183668 MIM:176398; AllianceGenome:HGNC:9526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PS34; PSG11; PSGII; PSBG-9; PSBG-11
Summary
The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]
Expression
Restricted expression toward placenta (RPKM 51.2) See more
Orthologs
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Genomic context

See PSG9 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43253282..43269530, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43757434..43773682, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 4 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10 Neighboring gene CEA cell adhesion molecule pseudogene 11 Neighboring gene CEA cell adhesion molecule pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transforming growth factor beta ligand-receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 9
Names
PS-beta-B
PS-beta-G-11
PS-beta-G-9
pregnancy specific beta-1-glycoprotein 11
pregnancy-specific beta-1 glycoprotein B
pregnancy-specific beta-1-glycoprotein 11 C-R domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301707.2NP_001288636.1  pregnancy-specific beta-1-glycoprotein 9 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Variants 2 and 3 encode isoforms of the same size, but contain internal differences.
    Source sequence(s)
    AK300229, BC005925, DC380417, M34481
    Consensus CDS
    CCDS77312.1
    UniProtKB/Swiss-Prot
    Q00887
    UniProtKB/TrEMBL
    B4DTI5, E7EW65, Q05DN5
    Related
    ENSP00000396753.2, ENST00000443718.7
    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:149236
    Ig; Immunoglobulin domain
  2. NM_001301708.2NP_001288637.1  pregnancy-specific beta-1-glycoprotein 9 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001288637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. Variants 2 and 3 encode isoforms of the same size, but contain internal differences.
    Source sequence(s)
    BC005925, DC380417, M34481
    Consensus CDS
    CCDS77314.1
    UniProtKB/Swiss-Prot
    Q00887
    UniProtKB/TrEMBL
    M0R0U8, Q05DN5
    Related
    ENSP00000471453.1, ENST00000593948.5
    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  3. NM_001301709.2NP_001288638.1  pregnancy-specific beta-1-glycoprotein 9 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001288638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive, alternate in-frame exons in the coding region, compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    BC005925, DC380417, M34481, U25987
    Consensus CDS
    CCDS77311.1
    UniProtKB/Swiss-Prot
    Q00887
    UniProtKB/TrEMBL
    G3XAA7, Q05DN5, Q13178
    Related
    ENSP00000291752.4, ENST00000291752.9
    Conserved Domains (3) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:153227
    IG_like; Immunoglobulin like
    pfam13895
    Location:149227
    Ig_2; Immunoglobulin domain
  4. NM_002784.5NP_002775.3  pregnancy-specific beta-1-glycoprotein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002775.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC005925, DC380417, M34481
    Consensus CDS
    CCDS12618.1
    UniProtKB/Swiss-Prot
    Q00887
    UniProtKB/TrEMBL
    Q05DN5
    Related
    ENSP00000270077.3, ENST00000270077.8
    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43253282..43269530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027007.2XP_016882496.1  pregnancy-specific beta-1-glycoprotein 9 isoform X5

    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. XM_017027006.2XP_016882495.1  pregnancy-specific beta-1-glycoprotein 9 isoform X4

    UniProtKB/TrEMBL
    M0R0E4
    Related
    ENSP00000471174.1, ENST00000596730.1
  3. XM_017027005.2XP_016882494.1  pregnancy-specific beta-1-glycoprotein 9 isoform X2

  4. XM_005259075.4XP_005259132.1  pregnancy-specific beta-1-glycoprotein 9 isoform X3

    See identical proteins and their annotated locations for XP_005259132.1

    UniProtKB/Swiss-Prot
    Q00887
    Related
    ENSP00000244293.7, ENST00000244293.11
    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  5. XM_017027004.2XP_016882493.1  pregnancy-specific beta-1-glycoprotein 9 isoform X1

    Conserved Domains (4) summary
    cd05774
    Location:36133
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
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