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PSG7 pregnancy specific beta-1-glycoprotein 7 [ Homo sapiens (human) ]

Gene ID: 5676, updated on 5-Aug-2022

Summary

Official Symbol
PSG7provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 7provided by HGNC
Primary source
HGNC:HGNC:9524
See related
Ensembl:ENSG00000221878 MIM:176396; AllianceGenome:HGNC:9524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG1; PSGGA; PSBG-7; PS-beta-G-7
Summary
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Restricted expression toward placenta (RPKM 24.2) See more
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Genomic context

See PSG7 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42924132..42937207, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45743086..45756176, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43428284..43441359, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 1 Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene CEA cell adhesion molecule pseudogene 7 Neighboring gene pregnancy specific beta-1-glycoprotein 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative pregnancy-specific beta-1-glycoprotein 7
Names
pregnancy-specific glycoprotein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206650.2NP_001193579.1  putative pregnancy-specific beta-1-glycoprotein 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC093055, BC136401, BP321474, BX952498, DB381347, T29414
    Consensus CDS
    CCDS77310.1
    UniProtKB/TrEMBL
    A0A096LNM5
    Related
    ENSP00000485117.1, ENST00000623675.3
    Conserved Domains (3) summary
    smart00410
    Location:217289
    IG_like; Immunoglobulin like
    pfam13895
    Location:213291
    Ig_2; Immunoglobulin domain
    cl11960
    Location:26114
    Ig; Immunoglobulin domain
  2. NM_002783.3NP_002774.2  putative pregnancy-specific beta-1-glycoprotein 7 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longest isoform (1). This version of transcript variant 1 represents the protein-coding minor allele. A second version of transcript variant 1 represents the major allele of this polymorphic locus with a mismatch compared to the reference genome sequence.
    Source sequence(s)
    AC093055, AL546656, BC030979, BG434892, BX952498, DC380850, T29414, U18467
    UniProtKB/Swiss-Prot
    Q13046, Q15232
    UniProtKB/TrEMBL
    A0A087WSZ1
    Related
    ENSP00000421986.1, ENST00000406070.7
    Conserved Domains (3) summary
    pfam13895
    Location:335413
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RNA

  1. NR_172123.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, non-coding) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This version of transcript variant 1 represents the non protein-coding major allele of this polymorphic locus with a mismatch compared to the reference genome sequence. A second version of transcript variant 1 represents the protein-coding minor allele.
    Source sequence(s)
    AC005260, AC093055, BC030979

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42924132..42937207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45743086..45756176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290042.1: Suppressed sequence

    Description
    NM_001290042.1: This RefSeq was removed because it is redundant with another RefSeq (NM_002783.3), when matched to the current reference genome assembly sequence.