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Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 56752, updated on 5-Feb-2023

Summary

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Official Symbol
Aldh9a1provided by MGI
Official Full Name
aldehyde dehydrogenase 9, subfamily A1provided by MGI
Primary source
MGI:MGI:1861622
See related
Ensembl:ENSMUSG00000026687 AllianceGenome:MGI:1861622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abaldh; ESTM40; Tmabadh; TMABA-DH
Summary
Enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Acts upstream of or within carnitine metabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; metanephros; and nervous system. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 54.7), liver adult (RPKM 50.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aldh9a1 in Genome Data Viewer
Location:
1; 1 H2.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167177532..167196099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167349963..167368530)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene predicted gene, 24182 Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α. Wen G, et al. Biochim Biophys Acta, 2012 May. PMID 22285688
  2. Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. Vaz FM, et al. J Biol Chem, 2000 Mar 10. PMID 10702312
  3. Etomoxir regulates the differentiation of male germ cells by specifically reducing H3K27ac level. Xu Y, et al. BMC Dev Biol, 2021 Feb 1. PMID 33517883, Free PMC Article
  4. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Hitzemann R, et al. Alcohol Clin Exp Res, 2004 Oct. PMID 15597075
  5. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Levi BP, et al. Blood, 2009 Feb 19. PMID 18971422, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMABA-DH gene is a direct PPARalpha target gene. this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake.
    Title: The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables amine binding ISO
Inferred from Sequence Orthology
more info
  
enables aminobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables aminobutyraldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carnitine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
4-trimethylaminobutyraldehyde dehydrogenase
Names
aldehyde dehydrogenase family 9 member A1
gamma-aminobutyraldehyde dehydrogenase
NP_064377.2
XP_006497013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402830.1 → NP_001389759.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970

  2. NM_001402839.1 → NP_001389768.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970

  3. NM_001402840.1 → NP_001389769.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970

  4. NM_001402844.1 → NP_001389773.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113970

  5. NM_001402845.1 → NP_001389774.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113970

  6. NM_001402846.1 → NP_001389775.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113970

  7. NM_001405095.1 → NP_001392024.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113970

  8. NM_019993.4 → NP_064377.2  4-trimethylaminobutyraldehyde dehydrogenase isoform 1 precursor

    See identical proteins and their annotated locations for NP_064377.2

    Status: VALIDATED

    Source sequence(s)
    AC113970
    Consensus CDS
    CCDS35765.1
    UniProtKB/Swiss-Prot
    Q9JLJ2
    UniProtKB/TrEMBL
    Q3TMT4, Q3U367, Q3V1N7
    Related
    ENSMUSP00000028004.10, ENSMUST00000028004.11
    Conserved Domains (1) summary
    cd07090
    Location:55 → 512
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167177532..167196099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496950.4 → XP_006497013.1  4-trimethylaminobutyraldehyde dehydrogenase isoform X1

    Conserved Domains (1) summary
    cl11961
    Location:1 → 312
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLJ2.1 GenPept UniProtKB/Swiss-Prot:Q9JLJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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