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Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 56752, updated on 8-Jan-2023

Summary

Official Symbol
Aldh9a1provided by MGI
Official Full Name
aldehyde dehydrogenase 9, subfamily A1provided by MGI
Primary source
MGI:MGI:1861622
See related
Ensembl:ENSMUSG00000026687 AllianceGenome:MGI:1861622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abaldh; ESTM40; Tmabadh; TMABA-DH
Summary
Enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Acts upstream of or within carnitine metabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; metanephros; and nervous system. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 54.7), liver adult (RPKM 50.7) and 28 other tissues See more
Orthologs
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Genomic context

See Aldh9a1 in Genome Data Viewer
Location:
1; 1 H2.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167177532..167196099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167349963..167368530)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene predicted gene, 24182 Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within carnitine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
4-trimethylaminobutyraldehyde dehydrogenase
Names
aldehyde dehydrogenase family 9 member A1
gamma-aminobutyraldehyde dehydrogenase
NP_064377.2
XP_006497013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402830.1NP_001389759.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970
  2. NM_001402839.1NP_001389768.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970
  3. NM_001402840.1NP_001389769.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113970
  4. NM_001402844.1NP_001389773.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113970
  5. NM_001402845.1NP_001389774.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113970
  6. NM_001402846.1NP_001389775.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113970
  7. NM_001405095.1NP_001392024.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113970
  8. NM_019993.4NP_064377.2  4-trimethylaminobutyraldehyde dehydrogenase isoform 1 precursor

    See identical proteins and their annotated locations for NP_064377.2

    Status: VALIDATED

    Source sequence(s)
    AC113970
    Consensus CDS
    CCDS35765.1
    UniProtKB/Swiss-Prot
    Q9JLJ2
    UniProtKB/TrEMBL
    Q3TMT4, Q3U367, Q3V1N7
    Related
    ENSMUSP00000028004.10, ENSMUST00000028004.11
    Conserved Domains (1) summary
    cd07090
    Location:55512
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167177532..167196099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496950.4XP_006497013.1  4-trimethylaminobutyraldehyde dehydrogenase isoform X1

    Conserved Domains (1) summary
    cl11961
    Location:1312
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily