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Lat2 linker for activation of T cells family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 56743, updated on 26-Sep-2022

Summary

Official Symbol
Lat2provided by MGI
Official Full Name
linker for activation of T cells family, member 2provided by MGI
Primary source
MGI:MGI:1926479
See related
Ensembl:ENSMUSG00000040751 AllianceGenome:MGI:1926479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAB; NTAL; WSCR5; Wbscr5; Wbscr15
Summary
Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to act upstream of or within adaptive immune response and mast cell degranulation. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 8.2), mammary gland adult (RPKM 2.7) and 23 other tissues See more
Orthologs
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Genomic context

See Lat2 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134628957..134648637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134600103..134619783, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene replication factor C (activator 1) 2 Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene LIM-domain containing, protein kinase Neighboring gene predicted gene 10369

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response-regulating signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
linker for activation of T-cells family member 2
Names
Williams-Beuren syndrome chromosome region 5 homolog
linker for activation of B-cells
membrane-associated adapter molecule
non-T cell activation linker
williams-Beuren syndrome chromosomal region 15 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020044.3NP_064428.1  linker for activation of T-cells family member 2 isoform a precursor

    See identical proteins and their annotated locations for NP_064428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK138953, AK143533
    Consensus CDS
    CCDS39312.1
    UniProtKB/Swiss-Prot
    Q9JHL0, Q9JJ29
    Related
    ENSMUSP00000046900.7, ENSMUST00000036362.13
    Conserved Domains (1) summary
    pfam15703
    Location:29197
    LAT2; Linker for activation of T-cells family member 2
  2. NM_022964.4NP_075253.2  linker for activation of T-cells family member 2 isoform b precursor

    See identical proteins and their annotated locations for NP_075253.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK138953, AK143533, AK162321
    Consensus CDS
    CCDS39311.1
    UniProtKB/Swiss-Prot
    Q9JHL0
    Related
    ENSMUSP00000076824.5, ENSMUST00000077636.8
    Conserved Domains (1) summary
    pfam15703
    Location:29185
    LAT2; Linker for activation of T-cells family member 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134628957..134648637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504456.5XP_006504519.1  linker for activation of T-cells family member 2 isoform X5

    Conserved Domains (1) summary
    pfam15703
    Location:43138
    LAT2; Linker for activation of T-cells family member 2
  2. XM_006504455.4XP_006504518.1  linker for activation of T-cells family member 2 isoform X4

    Conserved Domains (1) summary
    pfam15703
    Location:80162
    LAT2; Linker for activation of T-cells family member 2
  3. XM_006504453.4XP_006504516.1  linker for activation of T-cells family member 2 isoform X3

    Conserved Domains (1) summary
    pfam15703
    Location:92174
    LAT2; Linker for activation of T-cells family member 2
  4. XM_006504451.4XP_006504514.1  linker for activation of T-cells family member 2 isoform X1

    See identical proteins and their annotated locations for XP_006504514.1

    UniProtKB/Swiss-Prot
    Q9JHL0, Q9JJ29
    Conserved Domains (1) summary
    pfam15703
    Location:29197
    LAT2; Linker for activation of T-cells family member 2
  5. XM_006504452.2XP_006504515.1  linker for activation of T-cells family member 2 isoform X2

    See identical proteins and their annotated locations for XP_006504515.1

    UniProtKB/Swiss-Prot
    Q9JHL0
    Conserved Domains (1) summary
    pfam15703
    Location:29185
    LAT2; Linker for activation of T-cells family member 2
  6. XM_006504450.2XP_006504513.1  linker for activation of T-cells family member 2 isoform X1

    See identical proteins and their annotated locations for XP_006504513.1

    UniProtKB/Swiss-Prot
    Q9JHL0, Q9JJ29
    Related
    ENSMUSP00000143977.2, ENSMUST00000200998.4
    Conserved Domains (1) summary
    pfam15703
    Location:29197
    LAT2; Linker for activation of T-cells family member 2