ahsg2 alpha-2-HS-glycoprotein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ahsg2provided by ZNC
Official Full Name: alpha-2-HS-glycoprotein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1133
See related: Ensembl:ENSDARG00000069293 AllianceGenome:ZFIN:ZDB-GENE-030131-1133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb60d10; wu:fb60d10; si:cu104710.4; si:ch73-252g14.4
Summary: Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular region. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10134345..10141741)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10336525..10343921)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:238392

Z9746 (e-PCR)
- UniSTS:34134

fb60d10.x1 (e-PCR)
- UniSTS:203365

Z4662 (e-PCR)
- UniSTS:67265

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-2-HS-glycoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100029.1 → NP_001093499.1 alpha-2-HS-glycoprotein 2

Status: PROVISIONAL

Source sequence(s)

CU104710

UniProtKB/TrEMBL

A0A8M1NDP2, A5WWI5

Related

ENSDARP00000091498.4, ENSDART00000100725.5

Conserved Domains (1) summary

cl09238
Location:174 → 258

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.