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Rec8 REC8 meiotic recombination protein [ Mus musculus (house mouse) ]

Gene ID: 56739, updated on 8-Feb-2024

Summary

Official Symbol
Rec8provided by MGI
Official Full Name
REC8 meiotic recombination proteinprovided by MGI
Primary source
MGI:MGI:1929645
See related
Ensembl:ENSMUSG00000002324 AllianceGenome:MGI:1929645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mrec; Rec8L1
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including gamete generation; seminiferous tubule development; and synaptonemal complex assembly. Located in kinetochore; lateral element; and male germ cell nucleus. Part of nuclear meiotic cohesin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human REC8 (REC8 meiotic recombination protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 25.9), duodenum adult (RPKM 18.4) and 17 other tissues See more
Orthologs
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Genomic context

See Rec8 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55855459..55862852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55618002..55625395)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9 Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in meiotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within oocyte maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within seminiferous tubule development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cohesin complex IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meiotic recombination protein REC8 homolog
Names
REC8-like 1
cohesin Rec8p
meiotic cohesion Rec8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360389.1NP_001347318.1  meiotic recombination protein REC8 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC174678, BC052155
    Conserved Domains (1) summary
    pfam04824
    Location:427481
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
  2. NM_001360390.1NP_001347319.1  meiotic recombination protein REC8 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC174678, BC052155
    Conserved Domains (1) summary
    pfam04824
    Location:331385
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
  3. NM_020002.3NP_064386.2  meiotic recombination protein REC8 homolog isoform 1

    See identical proteins and their annotated locations for NP_064386.2

    Status: VALIDATED

    Source sequence(s)
    AC174678, AU080225, BC052155
    Consensus CDS
    CCDS27120.1
    UniProtKB/Swiss-Prot
    Q3UIN9, Q8C5S7, Q9JK52
    Related
    ENSMUSP00000002395.8, ENSMUST00000002395.8
    Conserved Domains (2) summary
    pfam04824
    Location:536590
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1112
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55855459..55862852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001781136.2 RNA Sequence