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PSG5 pregnancy specific beta-1-glycoprotein 5 [ Homo sapiens (human) ]

Gene ID: 5673, updated on 11-Jun-2021

Summary

Official Symbol
PSG5provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 5provided by HGNC
Primary source
HGNC:HGNC:9522
See related
Ensembl:ENSG00000204941 MIM:176394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG; FL-NCA-3
Summary
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 117.8) See more
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Genomic context

See PSG5 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43167743..43186536, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43671895..43690688, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 2 Neighboring gene CEA cell adhesion molecule pseudogene 9 Neighboring gene uncharacterized LOC107985349 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 4 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 5
Names
PS-beta-G-5
PSBG-5
Pregnancy-specific beta-1-glycoprotein-5
fetal liver non-specific cross-reactive antigen 3
pregnancy-specific beta 1 glycoprotein
pregnancy-specific glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130014.2NP_001123486.1  pregnancy-specific beta-1-glycoprotein 5 precursor

    See identical proteins and their annotated locations for NP_001123486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' exon, as compared to variant 1.
    Source sequence(s)
    AA151017, BC012607, BG622527, DA835167, M25384, M73713
    Consensus CDS
    CCDS12617.1
    UniProtKB/Swiss-Prot
    Q15238
    UniProtKB/TrEMBL
    A0A024R0S1
    Related
    ENSP00000386008.1, ENST00000407356.5
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. NM_002781.4NP_002772.3  pregnancy-specific beta-1-glycoprotein 5 precursor

    See identical proteins and their annotated locations for NP_002772.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012607, BG621332, BG622527, DA835167, M25384
    Consensus CDS
    CCDS12617.1
    UniProtKB/Swiss-Prot
    Q15238
    UniProtKB/TrEMBL
    A0A024R0S1
    Related
    ENSP00000344413.6, ENST00000342951.11
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43167743..43186536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027003.1XP_016882492.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q15238
    UniProtKB/TrEMBL
    A0A024R0S1
    Conserved Domains (4) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. XM_011527132.3XP_011525434.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

    Conserved Domains (1) summary
    cd05774
    Location:36138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
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