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Tdo2 tryptophan 2,3-dioxygenase [ Mus musculus (house mouse) ]

Gene ID: 56720, updated on 1-Mar-2024

Summary

Official Symbol
Tdo2provided by MGI
Official Full Name
tryptophan 2,3-dioxygenaseprovided by MGI
Primary source
MGI:MGI:1928486
See related
Ensembl:ENSMUSG00000028011 AllianceGenome:MGI:1928486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TO; TDO; chky
Summary
Predicted to enable several functions, including heme binding activity; identical protein binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in cerebellum; liver; male reproductive gland or organ; and small intestine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 173.8) See more
Orthologs
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Genomic context

See Tdo2 in Genome Data Viewer
Location:
3 E3; 3 35.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (81865719..81883035, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (81958412..81975728, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102640985 Neighboring gene predicted gene, 22531 Neighboring gene STARR-seq mESC enhancer starr_08032 Neighboring gene STARR-positive B cell enhancer ABC_E3439 Neighboring gene STARR-positive B cell enhancer ABC_E10186 Neighboring gene cathepsin O Neighboring gene acid-sensing ion channel family member 5 Neighboring gene guanylate cyclase 1, soluble, beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables tryptophan 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tryptophan 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophan catabolic process to acetyl-CoA IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tryptophan catabolic process to acetyl-CoA ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan metabolic process ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tryptophan 2,3-dioxygenase
Names
TRPO
tdo variant1
tdo variant2
tryptamin 2,3-dioxygenase
tryptophan oxygenase
tryptophan pyrrolase
tryptophanase
NP_064295.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019911.2NP_064295.2  tryptophan 2,3-dioxygenase

    See identical proteins and their annotated locations for NP_064295.2

    Status: PROVISIONAL

    Source sequence(s)
    BC018390
    Consensus CDS
    CCDS17427.1
    UniProtKB/Swiss-Prot
    P48776
    UniProtKB/TrEMBL
    C5NSA7, Q8VCW3
    Related
    ENSMUSP00000029645.9, ENSMUST00000029645.14
    Conserved Domains (1) summary
    pfam03301
    Location:26372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    81865719..81883035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)