U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brinp1 bone morphogenic protein/retinoic acid inducible neural specific 1 [ Mus musculus (house mouse) ]

Gene ID: 56710, updated on 8-Feb-2024

Summary

Official Symbol
Brinp1provided by MGI
Official Full Name
bone morphogenic protein/retinoic acid inducible neural specific 1provided by MGI
Primary source
MGI:MGI:1928478
See related
Ensembl:ENSMUSG00000028351 AllianceGenome:MGI:1928478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dbc1; BRINP; Fam5a; Dbccr1
Summary
Involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Acts upstream of or within several processes, including behavioral fear response; maternal behavior; and short-term memory. Predicted to be located in cytoplasm. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Is expressed in central nervous system; dorsal root ganglion; and submandibular gland primordium. Used to study attention deficit hyperactivity disorder and autism spectrum disorder. Orthologous to human BRINP1 (BMP/retinoic acid inducible neural specific 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 28.4), frontal lobe adult (RPKM 23.2) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Brinp1 in Genome Data Viewer
Location:
4 C1; 4 35.03 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (68679609..68872634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (68761372..68954397, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10493 Neighboring gene STARR-seq mESC enhancer starr_10494 Neighboring gene t-complex protein 1, pseudogene 1 Neighboring gene predicted gene 12911 Neighboring gene STARR-seq mESC enhancer starr_10495 Neighboring gene STARR-seq mESC enhancer starr_10496 Neighboring gene STARR-seq mESC enhancer starr_10497 Neighboring gene STARR-seq mESC enhancer starr_10498 Neighboring gene STARR-seq mESC enhancer starr_10499 Neighboring gene STARR-seq mESC enhancer starr_10500 Neighboring gene predicted gene, 42296 Neighboring gene predicted gene, 24697

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system neuron development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
BMP/retinoic acid-inducible neural-specific protein 1
Names
BMP/retinoic acid-inducible neural-specific protein (BRINP)
deleted in bladder cancer chromosome region candidate 1
deleted in bladder cancer protein 1 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019967.2NP_064351.2  BMP/retinoic acid-inducible neural-specific protein 1 precursor

    See identical proteins and their annotated locations for NP_064351.2

    Status: VALIDATED

    Source sequence(s)
    AB060589, AK045420
    Consensus CDS
    CCDS18272.1
    UniProtKB/Swiss-Prot
    Q80ZL2, Q812F0, Q8C1C9, Q920P3, Q920P4, Q9QXL0
    Related
    ENSMUSP00000030036.6, ENSMUST00000030036.6
    Conserved Domains (1) summary
    smart00457
    Location:73251
    MACPF; membrane-attack complex / perforin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    68679609..68872634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)