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PSG3 pregnancy specific beta-1-glycoprotein 3 [ Homo sapiens (human) ]

Gene ID: 5671, updated on 2-Nov-2024

Summary

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Official Symbol
PSG3provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 3provided by HGNC
Primary source
HGNC:HGNC:9520
See related
Ensembl:ENSG00000221826 MIM:176392; AllianceGenome:HGNC:9520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 164.7) See more
Orthologs
all
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Genomic context

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See PSG3 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42721642..42740481, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45540609..45559440, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43225794..43244633, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule pseudogene 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:43179943-43180536 Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43245994-43246209 Neighboring gene pregnancy specific beta-1-glycoprotein 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278258-43278758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278759-43279259 Neighboring gene CEA cell adhesion molecule pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1-glycoprotein gene family. Streydio C, et al. Genomics, 1990 Aug. PMID 2387594
  2. Expression of CEA-related genes in the first trimester human placenta. McLenachan T, et al. Biochem Biophys Res Commun, 1989 Aug 15. PMID 2788412
  3. Pregnancy specific beta 1-glycoprotein in human intestine. Shupert WL, et al. Mol Cell Biochem, 1993 Mar 24. PMID 8487756
  4. Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis. Borjigin J, et al. Biochem Biophys Res Commun, 1990 Jan 30. PMID 2302228
  5. Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein:homology with human carcinoembryonic antigen and related proteins. Rooney BC, et al. Gene, 1988 Nov 30. PMID 3265688

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in female pregnancy TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy-specific beta-1-glycoprotein 3
Names
PS-beta-G-3
PSBG-3
carcinoembryonic antigen SG5
pregnancy-specific glycoprotein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021016.4 → NP_066296.2  pregnancy-specific beta-1-glycoprotein 3 precursor

    See identical proteins and their annotated locations for NP_066296.2

    Status: VALIDATED

    Source sequence(s)
    BG620196, DA833589, M93061
    Consensus CDS
    CCDS12611.1
    UniProtKB/Swiss-Prot
    Q08265, Q16557, Q9BRW2, Q9UPL4, Q9UQ77
    UniProtKB/TrEMBL
    Q96QL5
    Related
    ENSP00000332215.5, ENST00000327495.10
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:339 → 413
    IG_like; Immunoglobulin like
    pfam13895
    Location:335 → 413
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42721642..42740481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527127.3 → XP_011525429.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

    Conserved Domains (3) summary
    cd05774
    Location:58 → 160
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:100 → 143
    IG_like; Immunoglobulin like
    cl11960
    Location:170 → 258
    Ig; Immunoglobulin domain

  2. XM_011527126.3 → XP_011525428.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

    UniProtKB/TrEMBL
    Q9UPK9
    Conserved Domains (4) summary
    cd05774
    Location:58 → 160
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:268 → 342
    IG_like; Immunoglobulin like
    pfam13895
    Location:264 → 342
    Ig_2; Immunoglobulin domain
    cl11960
    Location:170 → 258
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45540609..45559440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321488.1 → XP_054177463.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

  2. XM_054321487.1 → XP_054177462.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16557.2 GenPept UniProtKB/Swiss-Prot:Q16557

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