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TMEM9B TMEM9 domain family member B [ Homo sapiens (human) ]

Gene ID: 56674, updated on 5-Aug-2018

Summary

Official Symbol
TMEM9Bprovided by HGNC
Official Full Name
TMEM9 domain family member Bprovided by HGNC
Primary source
HGNC:HGNC:1168
See related
Ensembl:ENSG00000175348 Vega:OTTHUMG00000165676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf15
Expression
Ubiquitous expression in thyroid (RPKM 35.7), colon (RPKM 33.6) and 25 other tissues See more
Orthologs

Genomic context

See TMEM9B in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (8947201..8965011, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8968840..8986553, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene A-kinase interacting protein 1 Neighboring gene chromosome 11 open reading frame 16 Neighboring gene achaete-scute family bHLH transcription factor 3 Neighboring gene TMEM9B antisense RNA 1 Neighboring gene nuclear receptor interacting protein 3 Neighboring gene uncharacterized LOC105376541 Neighboring gene signal peptide, CUB domain and EGF like domain containing 2 Neighboring gene microRNA 5691

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286094.1NP_001273023.1  transmembrane protein 9B isoform b

    See identical proteins and their annotated locations for NP_001273023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AA433929, AI346520, BC015884, BP242422, DA563443
    Consensus CDS
    CCDS66021.1
    UniProtKB/Swiss-Prot
    Q9NQ34
    Related
    ENSP00000311842.5, OTTHUMP00000230695, ENST00000309134.9, OTTHUMT00000385721
    Conserved Domains (1) summary
    pfam05434
    Location:1123
    Tmemb_9; TMEM9
  2. NM_001286095.1NP_001273024.1  transmembrane protein 9B isoform b

    See identical proteins and their annotated locations for NP_001273024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AA433929, AI346520, AK300712, AY359069, DC314550
    Consensus CDS
    CCDS66021.1
    UniProtKB/Swiss-Prot
    Q9NQ34
    UniProtKB/TrEMBL
    B7Z6P5
    Related
    ENSP00000431487.1, OTTHUMP00000230697, ENST00000525069.5, OTTHUMT00000385723
    Conserved Domains (1) summary
    pfam05434
    Location:1123
    Tmemb_9; TMEM9
  3. NM_020644.2NP_065695.1  transmembrane protein 9B isoform a precursor

    See identical proteins and their annotated locations for NP_065695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA433929, AI346520, AY359069, BP242422, DA563443
    Consensus CDS
    CCDS7796.1
    UniProtKB/Swiss-Prot
    Q9NQ34
    UniProtKB/TrEMBL
    Q543A1
    Related
    ENSP00000433361.1, OTTHUMP00000230696, ENST00000534025.5, OTTHUMT00000385722
    Conserved Domains (1) summary
    pfam05434
    Location:57197
    Tmemb_9; TMEM9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    8947201..8965011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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