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nr1i2 nuclear receptor subfamily 1, group I, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 565875, updated on 21-Apr-2024

Summary

Official Symbol
nr1i2provided by ZNC
Official Full Name
nuclear receptor subfamily 1, group I, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030903-3
See related
Ensembl:ENSDARG00000029766 AllianceGenome:ZFIN:ZDB-GENE-030903-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PXR
Summary
Enables nuclear receptor activity and steroid hormone receptor activity. Acts upstream of or within regulation of transcription, DNA-templated; response to toxic substance; and transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including adenohypophyseal placode; brain; heart; liver; and pleuroperitoneal region. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See nr1i2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9502523..9562617)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9524480..9584819)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-214p13.9 Neighboring gene cilia and flagella associated protein 91 Neighboring gene glycogen synthase kinase 3 beta, genome duplicate a Neighboring gene G protein-coupled receptor 156

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear steroid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 1 group I member 2
Names
pregnane X receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098617.2NP_001092087.2  nuclear receptor subfamily 1 group I member 2

    Status: VALIDATED

    Source sequence(s)
    CR848676
    UniProtKB/TrEMBL
    A0A8M2BET5, A5WYG8, B0V1H8
    Related
    ENSDARP00000061524.3, ENSDART00000061525.5
    Conserved Domains (2) summary
    cd06934
    Location:141425
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07162
    Location:45131
    NR_DBD_PXR; DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    9502523..9562617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167420.4XP_005167477.1  nuclear receptor subfamily 1 group I member 2 isoform X1

    UniProtKB/TrEMBL
    B0V1H8
    Related
    ENSDARP00000106185.2, ENSDART00000125174.4
    Conserved Domains (2) summary
    cd06934
    Location:141425
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07162
    Location:45131
    NR_DBD_PXR; DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers
  2. XM_021478724.1XP_021334399.1  nuclear receptor subfamily 1 group I member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QAV5, A5WYG8
    Conserved Domains (2) summary
    cd06934
    Location:128412
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07162
    Location:32118
    NR_DBD_PXR; DNA-binding domain of pregnane X receptor (PXRs) is composed of two C4-type zinc fingers