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MMP26 matrix metallopeptidase 26 [ Homo sapiens (human) ]

Gene ID: 56547, updated on 11-Jun-2021

Summary

Official Symbol
MMP26provided by HGNC
Official Full Name
matrix metallopeptidase 26provided by HGNC
Primary source
HGNC:HGNC:14249
See related
Ensembl:ENSG00000167346 MIM:605470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]
Expression
Restricted expression toward endometrium (RPKM 7.9) See more
Orthologs
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Genomic context

See MMP26 in Genome Data Viewer
Location:
11p15.4
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (4704784..4992429)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4726014..5013659)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376528 Neighboring gene olfactory receptor family 51 subfamily E member 2 Neighboring gene olfactory receptor family 51 subfamily C member 1 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily C member 4 pseudogene Neighboring gene keratin 8 pseudogene 49 Neighboring gene olfactory receptor family 51 subfamily F member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 4 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 1 Neighboring gene olfactory receptor family 51 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Y member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily R member 1 Neighboring gene olfactory receptor family 51 subfamily F member 2 Neighboring gene olfactory receptor family 51 subfamily A member 8 pseudogene Neighboring gene olfactory receptor family 51 subfamily S member 1 Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 51 subfamily H member 2 pseudogene Neighboring gene olfactory receptor family 51 subfamily T member 1 Neighboring gene olfactory receptor family 51 subfamily A member 6 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 7 Neighboring gene olfactory receptor family 51 subfamily G member 2 Neighboring gene olfactory receptor family 51 subfamily G member 1 Neighboring gene olfactory receptor family 51 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 4 Neighboring gene olfactory receptor family 51 subfamily A member 2 Neighboring gene olfactory receptor family 51 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily L member 1 Neighboring gene olfactory receptor family 51 subfamily P member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126590, MGC126592

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
matrix metalloproteinase-26
Names
MMP-26
endometase
matrilysin 2
NP_001371537.1
NP_068573.2
XP_011518521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384608.1NP_001371537.1  matrix metalloproteinase-26 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018375, AC090719, AC103710
    Conserved Domains (1) summary
    pfam00413
    Location:28183
    Peptidase_M10; Matrixin
  2. NM_021801.5NP_068573.2  matrix metalloproteinase-26 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_068573.2

    Status: REVIEWED

    Source sequence(s)
    AC018375, AC090719, AC103710
    Consensus CDS
    CCDS7752.1
    UniProtKB/Swiss-Prot
    Q9NRE1
    Related
    ENSP00000369753.1, ENST00000380390.6
    Conserved Domains (1) summary
    pfam00413
    Location:98253
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    4704784..4992429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520219.2XP_011518521.1  matrix metalloproteinase-26 isoform X1

    Conserved Domains (1) summary
    pfam00413
    Location:28183
    Peptidase_M10; Matrixin
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