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cers2b ceramide synthase 2b [ Danio rerio (zebrafish) ]

Gene ID: 565295, updated on 18-Sep-2024

Summary

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Official Symbol
cers2bprovided by ZNC
Official Full Name
ceramide synthase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110408-40
See related
Ensembl:ENSDARG00000058992 AllianceGenome:ZFIN:ZDB-GENE-110408-40
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-167h2.3
Summary
Predicted to enable sphingosine N-acyltransferase activity. Acts upstream of or within cellular response to ceramide. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including lens placode; mesoderm; otic vesicle; pleuroperitoneal region; and solid lens vesicle. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (1362218..1397106)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (1338324..1370924)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 4 Neighboring gene uncharacterized LOC101882672 Neighboring gene cugbp, Elav-like family member 3b Neighboring gene SIM bHLH transcription factor 1a Neighboring gene activating signal cointegrator 1 complex subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family. Brondolin M, et al. Dev Dyn, 2013 Feb. PMID 23203913
  2. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Mendelson K, et al. Elife, 2017 Sep 28. PMID 28956531, Free PMC Article
  3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to ceramide IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ceramide synthase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    1362218..1397106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_688576.8 → XP_693668.1  ceramide synthase 2

    UniProtKB/TrEMBL
    A0A8N7UV25, E7F9X7
    Related
    ENSDARP00000124271.1, ENSDART00000149299.3
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:75 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Nucleotide Protein Strain
Heading Accession and Version

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