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DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 [ Homo sapiens (human) ]

Gene ID: 56521, updated on 15-Apr-2019

Summary

Official Symbol
DNAJC12provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C12provided by HGNC
Primary source
HGNC:HGNC:28908
See related
Ensembl:ENSG00000108176 MIM:606060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JDP1; HPANBH4
Summary
This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 18.5), liver (RPKM 12.0) and 15 other tissues See more
Orthologs

Genomic context

See DNAJC12 in Genome Data Viewer
Location:
10q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (67796665..67838187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69556427..69597937, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Ser (TGA) 1-1 Neighboring gene ribosomal protein L21 pseudogene 92 Neighboring gene RNA, U6 small nuclear 1250, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 394, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 1 Neighboring gene RNA, U6 small nuclear 523, pseudogene Neighboring gene ribosomal protein L12 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 12
Names
DnaJ (Hsp40) homolog, subfamily C, member 12
J domain containing protein 1 (JDP1)
J domain protein 1
j domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021800.3NP_068572.1  dnaJ homolog subfamily C member 12 isoform a

    See identical proteins and their annotated locations for NP_068572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AF176012, AL133551, CB121724
    Consensus CDS
    CCDS7271.1
    UniProtKB/Swiss-Prot
    Q9UKB3
    UniProtKB/TrEMBL
    Q6IAH1
    Related
    ENSP00000225171.2, ENST00000225171.7
    Conserved Domains (2) summary
    COG2214
    Location:9164
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    pfam00226
    Location:1476
    DnaJ; DnaJ domain
  2. NM_201262.1NP_957714.1  dnaJ homolog subfamily C member 12 isoform b

    See identical proteins and their annotated locations for NP_957714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences compared to variant 1. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF176013, CB121724
    Consensus CDS
    CCDS7272.1
    UniProtKB/Swiss-Prot
    Q9UKB3
    Related
    ENSP00000343575.6, ENST00000339758.7
    Conserved Domains (1) summary
    pfam00226
    Location:1476
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    67796665..67838187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016432.2XP_016871921.1  dnaJ homolog subfamily C member 12 isoform X1

  2. XM_017016431.1XP_016871920.1  dnaJ homolog subfamily C member 12 isoform X1

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