Format

Send to:

Choose Destination

CCL28 C-C motif chemokine ligand 28 [ Homo sapiens (human) ]

Gene ID: 56477, updated on 8-Jul-2021

Summary

Official Symbol
CCL28provided by HGNC
Official Full Name
C-C motif chemokine ligand 28provided by HGNC
Primary source
HGNC:HGNC:17700
See related
Ensembl:ENSG00000151882 MIM:605240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEC; CCK1; SCYA28
Summary
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in salivary gland (RPKM 40.6), colon (RPKM 10.6) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CCL28 in Genome Data Viewer
Location:
5p12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (43356972..43412391, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43376747..43412493, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr5.1234 Neighboring gene 60S acidic ribosomal protein P1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10963 Neighboring gene transmembrane protein 267 Neighboring gene C5orf34 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-C motif chemokine 28
Names
CC chemokine CCL28
chemokine (C-C motif) ligand 28 splice variant chi
mucosae-associated epithelial chemokine
small inducible cytokine A28
small inducible cytokine subfamily A (Cys-Cys), member 28

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301873.2NP_001288802.1  C-C motif chemokine 28 isoform a precursor

    See identical proteins and their annotated locations for NP_001288802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC025457, AF110384, BX486632
    Consensus CDS
    CCDS3944.1
    UniProtKB/Swiss-Prot
    Q9NRJ3
    UniProtKB/TrEMBL
    A0N0Q3
    Related
    ENSP00000426424.1, ENST00000489442.5
    Conserved Domains (1) summary
    pfam00048
    Location:2886
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
  2. NM_001301874.2NP_001288803.1  C-C motif chemokine 28 isoform a precursor

    See identical proteins and their annotated locations for NP_001288803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AF266504, BX486632
    Consensus CDS
    CCDS3944.1
    UniProtKB/Swiss-Prot
    Q9NRJ3
    UniProtKB/TrEMBL
    A0N0Q3
    Conserved Domains (1) summary
    pfam00048
    Location:2886
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
  3. NM_001301875.2NP_001288804.1  C-C motif chemokine 28 isoform b

    See identical proteins and their annotated locations for NP_001288804.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate promoter, as evidenced by epigenomic data, and has an alternate 5' terminal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC025457, CD671712
    Consensus CDS
    CCDS78006.1
    UniProtKB/TrEMBL
    D6RC73
    Related
    ENSP00000422369.1, ENST00000513525.1
    Conserved Domains (1) summary
    pfam00048
    Location:239
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
  4. NM_148672.3NP_683513.1  C-C motif chemokine 28 isoform a precursor

    See identical proteins and their annotated locations for NP_683513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC025457, BX486632
    Consensus CDS
    CCDS3944.1
    UniProtKB/Swiss-Prot
    Q9NRJ3
    UniProtKB/TrEMBL
    A0N0Q3
    Related
    ENSP00000354416.4, ENST00000361115.4
    Conserved Domains (1) summary
    pfam00048
    Location:2886
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    43356972..43412391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_427660.2 RNA Sequence

  2. XR_925633.2 RNA Sequence

  3. XR_241706.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019846.3: Suppressed sequence

    Description
    NM_019846.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center