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Fads2 fatty acid desaturase 2 [ Mus musculus (house mouse) ]

Gene ID: 56473, updated on 8-Jan-2023

Summary

Official Symbol
Fads2provided by MGI
Official Full Name
fatty acid desaturase 2provided by MGI
Primary source
MGI:MGI:1930079
See related
Ensembl:ENSMUSG00000024665 AllianceGenome:MGI:1930079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fads2a; Fadsd2; 2900042M13Rik
Summary
Enables stearoyl-CoA 9-desaturase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Is expressed in several structures, including adrenal gland; genitourinary system; nervous system; and retina. Orthologous to human FADS2 (fatty acid desaturase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 555.1), liver adult (RPKM 281.5) and 21 other tissues See more
Orthologs
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Genomic context

See Fads2 in Genome Data Viewer
Location:
19; 19 A
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10040129..10078867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10062765..10101503, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAB3A interacting protein (rabin3)-like 1 Neighboring gene fatty acid desaturase 3 Neighboring gene predicted gene, 29917 Neighboring gene vesicle-associated membrane protein 3 pseudogene Neighboring gene fatty acid desaturase 1 Neighboring gene microRNA 6993

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
acyl-CoA 6-desaturase
Names
D6D
delta(6) desaturase
delta(6) fatty acid desaturase
NP_062673.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019699.2NP_062673.1  acyl-CoA 6-desaturase

    See identical proteins and their annotated locations for NP_062673.1

    Status: VALIDATED

    Source sequence(s)
    AC135670
    Consensus CDS
    CCDS29571.1
    UniProtKB/Swiss-Prot
    Q9Z0R9
    Related
    ENSMUSP00000025567.8, ENSMUST00000025567.9
    Conserved Domains (3) summary
    PLN03199
    Location:1439
    PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
    cd03506
    Location:162412
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
    pfam00173
    Location:2094
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10040129..10078867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)