U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snx1 sorting nexin 1 [ Mus musculus (house mouse) ]

Gene ID: 56440, updated on 5-Mar-2024

Summary

Official Symbol
Snx1provided by MGI
Official Full Name
sorting nexin 1provided by MGI
Primary source
MGI:MGI:1928395
See related
Ensembl:ENSMUSG00000032382 AllianceGenome:MGI:1928395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in neuron projection development. Acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including dendritic spine; early endosome; and postsynaptic density. Is active in postsynaptic density, intracellular component. Is extrinsic component of postsynaptic endosome membrane. Is expressed in embryo; epiblast; primitive endoderm; and yolk sac. Orthologous to human SNX1 (sorting nexin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 53.7), genital fat pad adult (RPKM 44.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Snx1 in Genome Data Viewer
Location:
9 C; 9 35.71 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65995409..66032168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66088127..66124886, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 1 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene death-associated protein kinase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66059936-66060237

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of postsynaptic endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component IEP
Inferred from Expression Pattern
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 
part_of retromer, tubulation complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019727.2NP_062701.2  sorting nexin-1

    See identical proteins and their annotated locations for NP_062701.2

    Status: VALIDATED

    Source sequence(s)
    AB019214, AF154120, BB198783, BC066189
    Consensus CDS
    CCDS52839.1
    UniProtKB/TrEMBL
    Q3U4S1, Q6NZD2
    Related
    ENSMUSP00000034946.9, ENSMUST00000034946.15
    Conserved Domains (4) summary
    cd07281
    Location:144267
    PX_SNX1; The phosphoinositide binding Phox Homology domain of Sorting Nexin 1
    cd07665
    Location:285518
    BAR_SNX1; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1
    COG5391
    Location:17511
    COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
    pfam03700
    Location:53129
    Sorting_nexin; Sorting nexin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65995409..66032168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)