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Fzr1 fizzy and cell division cycle 20 related 1 [ Mus musculus (house mouse) ]

Gene ID: 56371, updated on 11-Apr-2024

Summary

Official Symbol
Fzr1provided by MGI
Official Full Name
fizzy and cell division cycle 20 related 1provided by MGI
Primary source
MGI:MGI:1926790
See related
Ensembl:ENSMUSG00000020235 AllianceGenome:MGI:1926790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FZR; Fyr; Cdh1; FZR2; HCDH; HCDH1
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in negative regulation of cell aging and positive regulation of cell population proliferation. Acts upstream of or within lens fiber cell differentiation; proteolysis involved in cellular protein catabolic process; and regulation of meiotic nuclear division. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including central nervous system; liver; oocyte; sensory organ; and skeleton. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: CDH1 (GeneID 12550) and FZR1 (GeneID 56371) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
Expression
Ubiquitous expression in ovary adult (RPKM 80.2), testis adult (RPKM 77.0) and 28 other tissues See more
Orthologs
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Genomic context

See Fzr1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81202713..81214204, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81366879..81378370, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group 20B Neighboring gene STARR-positive B cell enhancer ABC_E1809 Neighboring gene STARR-seq mESC enhancer starr_27329 Neighboring gene STARR-positive B cell enhancer ABC_E11448 Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene tektin bundle interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_27331 Neighboring gene STARR-seq mESC enhancer starr_27332 Neighboring gene predicted gene, 48551 Neighboring gene deoxyhypusine hydroxylase/monooxygenase Neighboring gene microRNA 6913 Neighboring gene predicted gene, 48552

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fizzy-related protein homolog
Names
cdh1/Hct1 homolog
cell division cycle 20 related 1
fizzy/cell division cycle 20 related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019757.1NP_062731.1  fizzy-related protein homolog

    See identical proteins and their annotated locations for NP_062731.1

    Status: PROVISIONAL

    Source sequence(s)
    AF083809
    Consensus CDS
    CCDS24057.1
    UniProtKB/Swiss-Prot
    Q9R1K5
    UniProtKB/TrEMBL
    Q3TQ38, Q3U2B8, Q3U3D4
    Related
    ENSMUSP00000114203.2, ENSMUST00000140901.8
    Conserved Domains (2) summary
    cd00200
    Location:193471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232269
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81202713..81214204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)