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Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 [ Mus musculus (house mouse) ]

Gene ID: 56348, updated on 12-May-2024

Summary

Official Symbol
Hsd17b12provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 12provided by MGI
Primary source
MGI:MGI:1926967
See related
Ensembl:ENSMUSG00000027195 AllianceGenome:MGI:1926967
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kik1; KIK-I; 2610510O05Rik
Summary
Enables collagen binding activity; fibronectin binding activity; and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 41.7), liver E18 (RPKM 29.6) and 28 other tissues See more
Orthologs
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Genomic context

See Hsd17b12 in Genome Data Viewer
Location:
2 E1; 2 51.62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93863042..93988254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94032697..94157909, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05169 Neighboring gene predicted gene 13889 Neighboring gene alkB homolog 3, opposite strand 1 Neighboring gene alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93850845-93851104 Neighboring gene STARR-seq mESC enhancer starr_05171 Neighboring gene STARR-seq mESC enhancer starr_05172 Neighboring gene STARR-positive B cell enhancer ABC_E511 Neighboring gene MIR670 host gene (non-protein coding) Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:94018945-94019238 Neighboring gene predicted gene, 39885 Neighboring gene microRNA 129-2 Neighboring gene microRNA 129b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IEA
Inferred from Electronic Annotation
more info
 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables very-long-chain 3-oxoacyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid elongase complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
very-long-chain 3-oxoacyl-CoA reductase
Names
17-beta-HSD 12
17-beta-hydroxysteroid dehydrogenase 12
3-ketoacyl-CoA reductase
KAR
estradiol 17-beta-dehydrogenase 12
keratoadhesin
keratonectin
steroid dehydrogenase
NP_062631.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019657.4NP_062631.1  very-long-chain 3-oxoacyl-CoA reductase

    See identical proteins and their annotated locations for NP_062631.1

    Status: PROVISIONAL

    Source sequence(s)
    AL772372, BX284932
    Consensus CDS
    CCDS16458.1
    UniProtKB/Swiss-Prot
    O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39
    UniProtKB/TrEMBL
    Q0VGQ1
    Related
    ENSMUSP00000028619.5, ENSMUST00000028619.5
    Conserved Domains (3) summary
    cd05356
    Location:50288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    COG0300
    Location:46305
    DltE; Short-chain dehydrogenase [General function prediction only]
    cl21454
    Location:483
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93863042..93988254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)