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Rassf1 Ras association (RalGDS/AF-6) domain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 56289, updated on 5-Mar-2024

Summary

Official Symbol
Rassf1provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 1provided by MGI
Primary source
MGI:MGI:1928386
See related
Ensembl:ENSMUSG00000010067 AllianceGenome:MGI:1928386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
123F2; RDA32; NORE2A; REH3P21; Rassf1A; Rassf1B; Rassf1C
Summary
Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 22.7), testis adult (RPKM 20.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rassf1 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107428752..107439460)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107551434..107562267)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras association domain-containing protein 1
Names
123F protein
RASSF1A tumor suppressor
Ras association (RalGDS/AF-6) domain family 1
protein 123F2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243748.2NP_001230677.1  ras association domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001230677.1

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS57699.1
    UniProtKB/Swiss-Prot
    Q99MK9, Q9WUF5
    UniProtKB/TrEMBL
    A9YZW8, B0QZV7
    Related
    ENSMUSP00000091301.3, ENSMUST00000093786.9
    Conserved Domains (3) summary
    cd00029
    Location:52101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd17218
    Location:130286
    RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
    pfam16517
    Location:295334
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
  2. NM_001411798.1NP_001398727.1  ras association domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672219
    UniProtKB/TrEMBL
    Q3UIV8
  3. NM_001411799.1NP_001398728.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219
  4. NM_001411800.1NP_001398729.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219
  5. NM_001411801.1NP_001398730.1  ras association domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672219
  6. NM_019713.5NP_062687.1  ras association domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_062687.1

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23494.1
    UniProtKB/Swiss-Prot
    Q99MK9
    UniProtKB/TrEMBL
    Q3UIV8
    Related
    ENSMUSP00000010211.5, ENSMUST00000010211.7
    Conserved Domains (2) summary
    cd17218
    Location:60216
    RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
    pfam16517
    Location:225264
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107428752..107439460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)