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Mrpl12 mitochondrial ribosomal protein L12 [ Mus musculus (house mouse) ]

Gene ID: 56282, updated on 30-Apr-2024

Summary

Official Symbol
Mrpl12provided by MGI
Official Full Name
mitochondrial ribosomal protein L12provided by MGI
Primary source
MGI:MGI:1926273
See related
Ensembl:ENSMUSG00000039640 AllianceGenome:MGI:1926273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L12mt; Rpml12; MRP-L12; 0610034O11Rik; 1500031N16Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial transcription and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 45. Orthologous to human MRPL12 (mitochondrial ribosomal protein L12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 210.7), adrenal adult (RPKM 180.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 E2; 11 84.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120375463..120379580)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120484637..120488754)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 137 Neighboring gene STARR-positive B cell enhancer ABC_E260 Neighboring gene ADP-ribosylation factor-like 16 Neighboring gene HGF-regulated tyrosine kinase substrate Neighboring gene solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 Neighboring gene predicted gene, 39490

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
large ribosomal subunit protein bL12m
Names
39S ribosomal protein L12, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027204.3NP_081480.2  large ribosomal subunit protein bL12m precursor

    See identical proteins and their annotated locations for NP_081480.2

    Status: VALIDATED

    Source sequence(s)
    AK134816, BQ032019
    Consensus CDS
    CCDS25737.1
    UniProtKB/Swiss-Prot
    B1ATZ3, Q3TKJ3, Q99JS8, Q9DB15
    Related
    ENSMUSP00000044417.8, ENSMUST00000043627.8
    Conserved Domains (2) summary
    cd00387
    Location:63200
    Ribosomal_L7_L12; Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of ...
    COG0222
    Location:64201
    RplL; Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120375463..120379580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)