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Pex14 peroxisomal biogenesis factor 14 [ Mus musculus (house mouse) ]

Gene ID: 56273, updated on 8-Feb-2024

Summary

Official Symbol
Pex14provided by MGI
Official Full Name
peroxisomal biogenesis factor 14provided by MGI
Primary source
MGI:MGI:1927868
See related
Ensembl:ENSMUSG00000028975 AllianceGenome:MGI:1927868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pex14p
Summary
Predicted to enable several functions, including identical protein binding activity; protein N-terminus binding activity; and tubulin binding activity. Predicted to be involved in several processes, including peroxisome transport along microtubule; protein import into peroxisome matrix; and regulation of transcription, DNA-templated. Predicted to act upstream of or within protein transport. Located in peroxisomal membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 13A. Orthologous to human PEX14 (peroxisomal biogenesis factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 52.9), duodenum adult (RPKM 28.4) and 28 other tissues See more
Orthologs
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Genomic context

See Pex14 in Genome Data Viewer
Location:
4 E2; 4 78.87 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149044992..149184300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148960535..149099843, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene castor zinc finger 1 Neighboring gene STARR-seq mESC enhancer starr_12094 Neighboring gene STARR-seq mESC enhancer starr_12095 Neighboring gene predicted gene 15969 Neighboring gene predicted gene 13205 Neighboring gene predicted gene 17029 Neighboring gene VISTA enhancer mm1566 Neighboring gene predicted gene, 42351 Neighboring gene STARR-positive B cell enhancer ABC_E9626 Neighboring gene STARR-seq mESC enhancer starr_12102 Neighboring gene predicted gene, 46722 Neighboring gene bolA-like 3 pseudogene Neighboring gene DNA fragmentation factor, alpha subunit Neighboring gene cortistatin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of peroxisomal importomer complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal membrane protein PEX14
Names
PTS1 receptor-docking protein
peroxin-14
peroxisomal membrane anchor protein PEX14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019781.3NP_062755.1  peroxisomal membrane protein PEX14

    See identical proteins and their annotated locations for NP_062755.1

    Status: VALIDATED

    Source sequence(s)
    AL611967
    Consensus CDS
    CCDS18950.1
    UniProtKB/Swiss-Prot
    Q9R0A0
    Related
    ENSMUSP00000099506.5, ENSMUST00000103217.11
    Conserved Domains (1) summary
    pfam04695
    Location:25135
    Pex14_N; Peroxisomal membrane anchor protein (Pex14p) conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149044992..149184300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)