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BEX4 brain expressed X-linked 4 [ Homo sapiens (human) ]

Gene ID: 56271, updated on 21-Dec-2019

Summary

Official Symbol
BEX4provided by HGNC
Official Full Name
brain expressed X-linked 4provided by HGNC
Primary source
HGNC:HGNC:25475
See related
Ensembl:ENSG00000102409 MIM:300692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEXL1
Summary
This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in brain (RPKM 111.7), thyroid (RPKM 67.9) and 23 other tissues See more
Orthologs

Genomic context

See BEX4 in Genome Data Viewer
Location:
Xq22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103215092..103217246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102469996..102472128)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 59 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1663 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1665 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1666

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein BEX4
Names
BEX family member 4
BEX1-like protein 1
brain expressed X-linked-like 1
nerve growth factor receptor-associated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021339.1 RefSeqGene

    Range
    5017..7155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080425.4NP_001073894.1  protein BEX4

    See identical proteins and their annotated locations for NP_001073894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate non-coding exon in the 5' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI199874, AL035494, AV726729, BC015794, BC068069
    Consensus CDS
    CCDS35355.1
    UniProtKB/Swiss-Prot
    Q9NWD9
    Related
    ENSP00000361780.5, ENST00000372695.6
    Conserved Domains (1) summary
    pfam04538
    Location:15116
    BEX; Brain expressed X-linked like family
  2. NM_001127688.2NP_001121160.1  protein BEX4

    See identical proteins and their annotated locations for NP_001121160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI199874, AL035494, AL544124, AV726729
    Consensus CDS
    CCDS35355.1
    UniProtKB/Swiss-Prot
    Q9NWD9
    Related
    ENSP00000361776.3, ENST00000372691.3
    Conserved Domains (1) summary
    pfam04538
    Location:15116
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103215092..103217246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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