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WDR45B WD repeat domain 45B [ Homo sapiens (human) ]

Gene ID: 56270, updated on 7-Jan-2024

Summary

Official Symbol
WDR45Bprovided by HGNC
Official Full Name
WD repeat domain 45Bprovided by HGNC
Primary source
HGNC:HGNC:25072
See related
Ensembl:ENSG00000141580 MIM:609226; AllianceGenome:HGNC:25072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIPI3; WDR45L; WIPI-3; NEDSBAS
Summary
This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 30.3), esophagus (RPKM 20.3) and 25 other tissues See more
Orthologs
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Genomic context

See WDR45B in Genome Data Viewer
Location:
17q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82614562..82648444, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83488501..83522749, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80572438..80606320, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene forkhead box K2 Neighboring gene uncharacterized LOC105371942 Neighboring gene uncharacterized LOC124904132 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 9 Neighboring gene MPRA-validated peak3032 silencer Neighboring gene Sharpr-MPRA regulatory region 15512 Neighboring gene MPRA-validated peak3033 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9221 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:80605965-80606464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80622218-80622718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13014 Neighboring gene RAB40B, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80637586-80638111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80638112-80638636 Neighboring gene microRNA 4525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9224 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80660456-80661655 Neighboring gene uncharacterized LOC124904093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80661763-80662564

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TSC1-TSC2 complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WD repeat domain phosphoinositide-interacting protein 3
Names
WD repeat protein 45-like
WD repeat-containing protein 45-like
WD repeat-containing protein 45B
WDR45-like protein
WIPI3 long
WIPI49-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046895.1 RefSeqGene

    Range
    5092..38974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019613.4NP_062559.2  WD repeat domain phosphoinositide-interacting protein 3

    See identical proteins and their annotated locations for NP_062559.2

    Status: REVIEWED

    Source sequence(s)
    AA861045, AC124283, AM182326, CN262716
    Consensus CDS
    CCDS11815.2
    UniProtKB/Swiss-Prot
    A0A024R8U4, A0A218N098, O95328, Q2MCP6, Q5MNZ6, Q6IBN2
    Related
    ENSP00000376139.4, ENST00000392325.9
    Conserved Domains (2) summary
    sd00039
    Location:145183
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:25258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82614562..82648444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256377.6XP_005256434.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005256434.1

    Conserved Domains (2) summary
    sd00039
    Location:111149
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:46223
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_047436412.1XP_047292368.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X2

  3. XM_047436413.1XP_047292369.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X3

  4. XM_047436414.1XP_047292370.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X4

    UniProtKB/TrEMBL
    I3L4S6
    Related
    ENSP00000461488.1, ENST00000572583.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    83488501..83522749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316690.1XP_054172665.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X1

  2. XM_054316691.1XP_054172666.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X3

  3. XM_054316692.1XP_054172667.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X4

    UniProtKB/TrEMBL
    I3L4S6