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uof [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 5625562, updated on 24-Aug-2024

Summary

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Official Symbol
uof
Primary source
ECOCYC:G0-10580
Locus tag
b4637
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4461
Summary
The ryhB sRNA is an antisense regulator of uof translation, which is coupled to the downstream fur gene translation; the fur RBS is occluded by 5' mRNA secondary structure, which is opened by uof translation (Vecerek, 2007). [More information is available at EcoGene: EG14465]. Uof appears to function in an indirect role to regulate abundance of the iron-responsive transcriptional regulator Fur at the posttranscriptional level. [More information is available at EcoCyc: G0-10580].
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Genomic context

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Sequence:
NC_000913.3 (710639..710725, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chitooligosaccharide outer membrane channel Neighboring gene lipoprotein ChiQ Neighboring gene DNA-binding transcriptional dual regulator Fur Neighboring gene flavodoxin 1 Neighboring gene ribbon-helix-helix domain-containing protein YbfE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-induced bending as a transcriptional switch. Pérez-Martín J, et al. Science, 1993 May 7. PMID 8387228
  2. Control of Fur synthesis by the non-coding RNA RyhB and iron-responsive decoding. Vecerek B, et al. EMBO J, 2007 Feb 21. PMID 17268550, Free PMC Article
  3. OxyR and SoxRS regulation of fur. Zheng M, et al. J Bacteriol, 1999 Aug. PMID 10419964, Free PMC Article
  4. Small membrane proteins found by comparative genomics and ribosome binding site models. Hemm MR, et al. Mol Microbiol, 2008 Dec. PMID 19121005, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RyhB-regulated fur leader peptide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    710639..710725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001491546.1 RyhB-regulated fur leader peptide [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_001491546.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A8DYP9
    Conserved Domains (1) summary
    PRK14761
    Location:1 → 28
    PRK14761; fur leader peptide
Nucleotide Protein
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