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YLPM1 YLP motif containing 1 [ Homo sapiens (human) ]

Gene ID: 56252, updated on 4-Dec-2022

Summary

Official Symbol
YLPM1provided by HGNC
Official Full Name
YLP motif containing 1provided by HGNC
Primary source
HGNC:HGNC:17798
See related
Ensembl:ENSG00000119596 MIM:619766; AllianceGenome:HGNC:17798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP3; ZAP113; PPP1R169; C14orf170
Summary
Enables RNA binding activity. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 14.0), brain (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

See YLPM1 in Genome Data Viewer
Location:
14q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74763316..74837318)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68972425..69046421)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75230019..75304021)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene FCF1 rRNA-processing protein Neighboring gene uncharacterized LOC105370569 Neighboring gene uncharacterized LOC124903348 Neighboring gene prospero homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YLP motif-containing protein 1
Names
nuclear protein ZAP3
protein phosphatase 1, regulatory subunit 169

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411052.1NP_001397981.1  YLP motif-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007956
    Consensus CDS
    CCDS91906.1
    UniProtKB/TrEMBL
    F8VU51
  2. NM_019589.3NP_062535.2  YLP motif-containing protein 1

    See identical proteins and their annotated locations for NP_062535.2

    Status: VALIDATED

    Source sequence(s)
    AC007956, AK090435, AK095760, BC007792, BX102033, DB096717
    Consensus CDS
    CCDS45135.1
    UniProtKB/Swiss-Prot
    P49750, Q9P1V7
    UniProtKB/TrEMBL
    Q8NF45
    Related
    ENSP00000324463.7, ENST00000325680.12
    Conserved Domains (3) summary
    cl25887
    Location:12791403
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26098
    Location:18361971
    AAA_33; AAA domain
    cl28310
    Location:10851327
    Rho; Transcription termination factor Rho [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74763316..74837318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536966.3XP_011535268.1  YLP motif-containing protein 1 isoform X3

    Related
    ENSP00000449860.1, ENST00000549293.5
    Conserved Domains (1) summary
    pfam13671
    Location:14311566
    AAA_33; AAA domain
  2. XM_011536967.3XP_011535269.1  YLP motif-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    F8VU51
    Related
    ENSP00000447921.1, ENST00000552421.5
    Conserved Domains (1) summary
    pfam13671
    Location:11301269
    AAA_33; AAA domain
  3. XM_047431591.1XP_047287547.1  YLP motif-containing protein 1 isoform X2

  4. XM_005267860.4XP_005267917.1  YLP motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267917.1

    Conserved Domains (1) summary
    pfam13671
    Location:18361971
    AAA_33; AAA domain
  5. XM_047431592.1XP_047287548.1  YLP motif-containing protein 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68972425..69046421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)