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YLPM1 YLP motif containing 1 [ Homo sapiens (human) ]

Gene ID: 56252, updated on 2-Nov-2024

Summary

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Official Symbol
YLPM1provided by HGNC
Official Full Name
YLP motif containing 1provided by HGNC
Primary source
HGNC:HGNC:17798
See related
Ensembl:ENSG00000119596 MIM:619766; AllianceGenome:HGNC:17798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP3; ZAP113; PPP1R169; C14orf170
Summary
Enables RNA binding activity. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 14.0), brain (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

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See YLPM1 in Genome Data Viewer
Location:
14q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74763316..74837318)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68972425..69046421)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75230019..75304021)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8729 Neighboring gene FCF1 rRNA-processing protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8730 Neighboring gene uncharacterized LOC105370569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:75321384-75322583 Neighboring gene uncharacterized LOC124903348 Neighboring gene prospero homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Ulke-Lemée A, et al. Biochim Biophys Acta, 2007 Oct. PMID 17890166
  2. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
  3. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Sherrington R, et al. Nature, 1995 Jun 29. PMID 7596406
  4. Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. Linkermann A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19041431
  5. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. Mulkearns EE, et al. Mol Biol Cell, 2012 Apr. PMID 22323290, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZAP3 is a putative nucleoside kinase that targets protein phosphatase-1 through its highly conserved carboxy-terminal RVRW sequence.
    Title: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
YLP motif-containing protein 1
Names
nuclear protein ZAP3
protein phosphatase 1, regulatory subunit 169

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411052.1 → NP_001397981.1  YLP motif-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007956
    Consensus CDS
    CCDS91906.1
    UniProtKB/TrEMBL
    F8VU51
    Related
    ENSP00000447921.1, ENST00000552421.5

  2. NM_019589.3 → NP_062535.2  YLP motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_062535.2

    Status: VALIDATED

    Source sequence(s)
    AC007956, AK090435, AK095760, BC007792, BX102033, DB096717
    Consensus CDS
    CCDS45135.1
    UniProtKB/Swiss-Prot
    P49750, P49752, Q96I64, Q9P1V7
    UniProtKB/TrEMBL
    Q8NF45
    Related
    ENSP00000324463.7, ENST00000325680.12
    Conserved Domains (3) summary
    cl25887
    Location:1279 → 1403
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26098
    Location:1836 → 1971
    AAA_33; AAA domain
    cl28310
    Location:1085 → 1327
    Rho; Transcription termination factor Rho [Transcription]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74763316..74837318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536966.3 → XP_011535268.1  YLP motif-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q8NF45
    Related
    ENSP00000449860.1, ENST00000549293.5
    Conserved Domains (1) summary
    pfam13671
    Location:1431 → 1566
    AAA_33; AAA domain

  2. XM_047431591.1 → XP_047287547.1  YLP motif-containing protein 1 isoform X2

  3. XM_005267860.4 → XP_005267917.1  YLP motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267917.1

    UniProtKB/TrEMBL
    Q8NF45
    Conserved Domains (1) summary
    pfam13671
    Location:1836 → 1971
    AAA_33; AAA domain

  4. XM_047431592.1 → XP_047287548.1  YLP motif-containing protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68972425..69046421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376401.1 → XP_054232376.1  YLP motif-containing protein 1 isoform X3

  2. XM_054376400.1 → XP_054232375.1  YLP motif-containing protein 1 isoform X2

  3. XM_054376399.1 → XP_054232374.1  YLP motif-containing protein 1 isoform X1

  4. XM_054376402.1 → XP_054232377.1  YLP motif-containing protein 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49750.4 GenPept UniProtKB/Swiss-Prot:P49750

Gene LinkOut

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