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Htra1 HtrA serine peptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 56213, updated on 31-Mar-2024

Summary

Official Symbol
Htra1provided by MGI
Official Full Name
HtrA serine peptidase 1provided by MGI
Primary source
MGI:MGI:1929076
See related
Ensembl:ENSMUSG00000006205 AllianceGenome:MGI:1929076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L56; HTRA; Prss11; RSPP11
Summary
Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; limb; reproductive system; sensory organ; and skin. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 297.0), mammary gland adult (RPKM 75.1) and 14 other tissues See more
Orthologs
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Genomic context

See Htra1 in Genome Data Viewer
Location:
7 F3; 7 73.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130537933..130587388)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (130936203..130985658)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8213 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Neighboring gene predicted gene 5602 Neighboring gene STARR-seq mESC enhancer starr_20271 Neighboring gene microRNA 7061 Neighboring gene STARR-seq mESC enhancer starr_20273 Neighboring gene STARR-seq mESC enhancer starr_20276 Neighboring gene STARR-seq mESC enhancer starr_20277 Neighboring gene STARR-seq mESC enhancer starr_20278 Neighboring gene deleted in malignant brain tumors 1 Neighboring gene RIKEN cDNA 4933402N03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine protease HTRA1
Names
high-temperature requirement A serine peptidase 1
insulin-like growth factor binding protein 5 protease
protease, serine, 11 (Igf binding)
serine protease 11
NP_062510.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019564.3NP_062510.2  serine protease HTRA1 precursor

    See identical proteins and their annotated locations for NP_062510.2

    Status: VALIDATED

    Source sequence(s)
    AF179369, AI429470, CB193609
    Consensus CDS
    CCDS21908.1
    UniProtKB/Swiss-Prot
    Q8BN04, Q8BN05, Q91WS3, Q9QZK6, Q9R118
    Related
    ENSMUSP00000006367.8, ENSMUST00000006367.8
    Conserved Domains (5) summary
    smart00121
    Location:37111
    IB; Insulin growth factor-binding protein homologues
    smart00280
    Location:115155
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:154480
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:382473
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:204342
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    130537933..130587388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)