U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ptbp2 polypyrimidine tract binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 56195, updated on 18-Apr-2024

Summary

Official Symbol
Ptbp2provided by MGI
Official Full Name
polypyrimidine tract binding protein 2provided by MGI
Primary source
MGI:MGI:1860489
See related
Ensembl:ENSMUSG00000028134 AllianceGenome:MGI:1860489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptb2; nPTB; brPTB
Summary
Enables mRNA binding activity. Acts upstream of or within mRNA splice site selection and regulation of neural precursor cell proliferation. Part of spliceosomal complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 48.5), whole brain E14.5 (RPKM 48.4) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
3 G1; 3 52.18 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (119512390..119578296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (119718741..119784647, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08825 Neighboring gene predicted gene, 23432 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08826 Neighboring gene ribonucleotide reductase M2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08827 Neighboring gene predicted gene, 23733

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA splice site recognition IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA splice site recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polypyrimidine tract-binding protein 2
Names
RRM-type RNA-binding protein brPTB
brain-enriched PTB
brain-enriched polypyrimidine tract-binding protein
neural polypyrimidine tract-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310711.2NP_001297640.1  polypyrimidine tract-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001297640.1

    Status: VALIDATED

    Source sequence(s)
    AC111029
    Consensus CDS
    CCDS80010.1
    UniProtKB/Swiss-Prot
    Q7TNW7, Q91Z31, Q9CUW2, Q9QYC2, Q9R0V9
    Related
    ENSMUSP00000143510.2, ENSMUST00000200097.5
    Conserved Domains (1) summary
    TIGR01649
    Location:57531
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. NM_001428875.1NP_001415804.1  polypyrimidine tract-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC111029
  3. NM_001428876.1NP_001415805.1  polypyrimidine tract-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC111029
  4. NM_019550.3NP_062423.1  polypyrimidine tract-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_062423.1

    Status: VALIDATED

    Source sequence(s)
    AC111029
    Consensus CDS
    CCDS38616.1
    UniProtKB/Swiss-Prot
    Q91Z31
    Related
    ENSMUSP00000029780.8, ENSMUST00000029780.12
    Conserved Domains (1) summary
    TIGR01649
    Location:57532
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. NR_190519.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC111029
  2. NR_190520.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC111029
  3. NR_190521.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC111029
  4. NR_190522.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC111029

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    119512390..119578296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501731.2XP_006501794.1  polypyrimidine tract-binding protein 2 isoform X1

    Conserved Domains (1) summary
    TIGR01649
    Location:57537
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. XM_006501732.3XP_006501795.1  polypyrimidine tract-binding protein 2 isoform X2

    Conserved Domains (1) summary
    TIGR01649
    Location:57536
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. XR_001783719.3 RNA Sequence

  2. XR_375550.4 RNA Sequence

  3. XR_375549.3 RNA Sequence

  4. XR_001783718.3 RNA Sequence