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STK31 serine/threonine kinase 31 [ Homo sapiens (human) ]

Gene ID: 56164, updated on 1-Jun-2020

Summary

Official Symbol
STK31provided by HGNC
Official Full Name
serine/threonine kinase 31provided by HGNC
Primary source
HGNC:HGNC:11407
See related
Ensembl:ENSG00000196335 MIM:605790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDRD8; SGK396
Summary
This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 35.6) See more
Orthologs

Genomic context

See STK31 in Genome Data Viewer
Location:
7p15.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (23710140..23832515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (23749786..23872132)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 126 Neighboring gene FCF1 pseudogene 1 Neighboring gene family with sequence similarity 221 member A Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 7 Neighboring gene uncharacterized LOC105375188 Neighboring gene RNA, 5S ribosomal pseudogene 228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 31
Names
serine/threonine-protein kinase NYD-SPK
sugen kinase 396
testis tissue sperm-binding protein Li 78m
tudor domain containing 8
NP_001247433.1
NP_001247434.1
NP_113602.2
NP_116562.2
XP_006715821.1
XP_011513751.2
XP_011513752.1
XP_011513754.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260504.2NP_001247433.1  serine/threonine-protein kinase 31 isoform b

    See identical proteins and their annotated locations for NP_001247433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AA315045, AC003087, AC008176, AF332194, AK131214, DA533364
    Consensus CDS
    CCDS43556.1
    UniProtKB/Swiss-Prot
    Q9BXU1
    UniProtKB/TrEMBL
    A0A140VKG1, B3KY91
    Related
    ENSP00000346660.3, ENST00000354639.7
    Conserved Domains (3) summary
    cd04508
    Location:66106
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:6124
    TUDOR; Tudor domain
    cl21453
    Location:779898
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001260505.2NP_001247434.1  serine/threonine-protein kinase 31 isoform c

    See identical proteins and their annotated locations for NP_001247434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC003087, AC008176, AK302689
    Consensus CDS
    CCDS59049.1
    UniProtKB/Swiss-Prot
    Q9BXU1
    Related
    ENSP00000411852.2, ENST00000433467.6
    Conserved Domains (3) summary
    cd04508
    Location:89129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29147
    TUDOR; Tudor domain
    cl21453
    Location:802986
    PKc_like; Protein Kinases, catalytic domain
  3. NM_031414.5NP_113602.2  serine/threonine-protein kinase 31 isoform a

    See identical proteins and their annotated locations for NP_113602.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC003087, BC059374, DB065148
    Consensus CDS
    CCDS5386.1
    UniProtKB/Swiss-Prot
    Q9BXU1
    Related
    ENSP00000348132.3, ENST00000355870.8
    Conserved Domains (3) summary
    cd04508
    Location:89129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29147
    TUDOR; Tudor domain
    cl21453
    Location:802921
    PKc_like; Protein Kinases, catalytic domain
  4. NM_032944.4NP_116562.2  serine/threonine-protein kinase 31 isoform b

    See identical proteins and their annotated locations for NP_116562.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC003087, AC008176, BC059374, DB095141
    Consensus CDS
    CCDS43556.1
    UniProtKB/Swiss-Prot
    Q9BXU1
    UniProtKB/TrEMBL
    A0A140VKG1
    Conserved Domains (3) summary
    cd04508
    Location:66106
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:6124
    TUDOR; Tudor domain
    cl21453
    Location:779898
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_048542.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    23710140..23832515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515452.3XP_011513754.2  serine/threonine-protein kinase 31 isoform X3

  2. XM_011515449.3XP_011513751.2  serine/threonine-protein kinase 31 isoform X1

  3. XM_006715758.4XP_006715821.1  serine/threonine-protein kinase 31 isoform X4

    Conserved Domains (3) summary
    cd04508
    Location:89129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29147
    TUDOR; Tudor domain
    cl21453
    Location:624743
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011515450.1XP_011513752.1  serine/threonine-protein kinase 31 isoform X2

    See identical proteins and their annotated locations for XP_011513752.1

    UniProtKB/TrEMBL
    A0A140VKG1
    Conserved Domains (3) summary
    cd04508
    Location:66106
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:6124
    TUDOR; Tudor domain
    cl21453
    Location:779898
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122833.1: Suppressed sequence

    Description
    NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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