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Mad2l1 MAD2 mitotic arrest deficient-like 1 [ Mus musculus (house mouse) ]

Gene ID: 56150, updated on 22-Jan-2023

Summary

Official Symbol
Mad2l1provided by MGI
Official Full Name
MAD2 mitotic arrest deficient-like 1provided by MGI
Primary source
MGI:MGI:1860374
See related
Ensembl:ENSMUSG00000029910 AllianceGenome:MGI:1860374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAD2
Summary
Predicted to enable protein C-terminus binding activity and protein homodimerization activity. Involved in negative regulation of apoptotic process and positive regulation of mitotic cell cycle spindle assembly checkpoint. Acts upstream of or within mitotic sister chromatid segregation and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including kinetochore; nucleus; and spindle pole. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 32.4), CNS E11.5 (RPKM 26.2) and 15 other tissues See more
Orthologs
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Genomic context

See Mad2l1 in Genome Data Viewer
Location:
6 C1; 6 30.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (66512205..66518091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (66535221..66541107)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19764 Neighboring gene tropomyosin 3, related sequence 3 Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene vomeronasal 1 receptor 32 Neighboring gene aurora kinase B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113763

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mitotic metaphase/anaphase transition TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
part_of mitotic checkpoint complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
part_of mitotic spindle assembly checkpoint MAD1-MAD2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mitotic spindle assembly checkpoint MAD1-MAD2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitotic spindle assembly checkpoint protein MAD2A
Names
MAD2 (mitotic arrest deficient, homolog)-like 1
MAD2-like protein 1
mitotic arrest deficient 2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355624.1NP_001342553.1  mitotic spindle assembly checkpoint protein MAD2A

    Status: VALIDATED

    Source sequence(s)
    AC122874
    Consensus CDS
    CCDS20210.1
    UniProtKB/Swiss-Prot
    Q9JI53
    UniProtKB/TrEMBL
    A0A6P5PQ60, A0A8C6GCI9, Q5HZH8
    Related
    ENSMUSP00000112304.2, ENSMUST00000116605.8
    Conserved Domains (1) summary
    pfam02301
    Location:16191
    HORMA; HORMA domain
  2. NM_019499.5NP_062372.2  mitotic spindle assembly checkpoint protein MAD2A

    See identical proteins and their annotated locations for NP_062372.2

    Status: VALIDATED

    Source sequence(s)
    AC122874
    Consensus CDS
    CCDS20210.1
    UniProtKB/Swiss-Prot
    Q9JI53, Q9Z1B5
    UniProtKB/TrEMBL
    A0A6P5PQ60, A0A8C6GCI9, Q5HZH8
    Related
    ENSMUSP00000098897.2, ENSMUST00000101343.2
    Conserved Domains (1) summary
    pfam02301
    Location:16191
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    66512205..66518091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)