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Set SET nuclear oncogene [ Mus musculus (house mouse) ]

Gene ID: 56086, updated on 7-May-2024

Summary

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Official Symbol
Setprovided by MGI
Official Full Name
SET nuclear oncogeneprovided by MGI
Primary source
MGI:MGI:1860267
See related
Ensembl:ENSMUSG00000054766 AllianceGenome:MGI:1860267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAF-I; I-2PP2A; StF-IT-1; 2610030F17Rik; 5730420M11Rik
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; skin; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 163.2), CNS E14 (RPKM 62.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Set in Genome Data Viewer
Location:
2 B; 2 21.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29952074..29962589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30061996..30072577)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene protein kinase N3 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses. Zhang S, et al. Exp Mol Med, 2022 Oct. PMID 36224346, Free PMC Article
  2. SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes. Gao L, et al. Reprod Biol, 2022 Sep. PMID 35728284
  3. Distribution of SET/I2PP2A protein in gastrointestinal tissues. Umata K, et al. PLoS One, 2019. PMID 31557212, Free PMC Article
  4. Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. Dorard E, et al. Neurobiol Aging, 2016 Oct. PMID 27460148
  5. The N-terminal Set-β Protein Isoform Induces Neuronal Death. Trakhtenberg EF, et al. J Biol Chem, 2015 May 22. PMID 25833944, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes.
    Title: SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes.
  2. Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and beta-Catenin.
    Title: Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin.
  3. The data underscore the importance of SET oncoprotein during embryonic development and reveal both of the p53-dependent and the p53-independent functions of SET in vivo.
    Title: Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.
  4. co-immunofluorescent staining of mouse gastrointestinal tissues revealed that even though the positive rate is much lower than epithelial cells, SET protein is also expressed in non-epithelial cells, such as monocytes/macrophages, neural cells, myofibroblasts, and smooth muscle cells. Results indicate an extensive role of SET in a variety of cell types.
    Title: Distribution of SET/I2PP2A protein in gastrointestinal tissues.
  5. Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
    Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
  6. Presence of SET in the cytoplasm in Down Syndrome brains may play a role in the progression of the disease.
    Title: Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
  7. Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
    Title: Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.
  8. SET protein was expressed in spermatogonia and spermatocytes; the highest level was mainly in haploid and tetraploid cells of the prepubertal and adult groups, and Leydig cells of the adult and ageing groups. There was a low expression in Sertoli cells.
    Title: Expression of the SET protein in testes of mice at different developmental stages.
  9. The presence of full-length SET in the neuronal cytoplasm is sufficient to impair PP2A methylation and activity, leading to tau hyperphosphorylation.
    Title: Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.
  10. SET/PP2A system regulates testosterone production in ovarian follicles in vitro.
    Title: SET/PP2A system regulates androgen production in ovarian follicles in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein SET
Names
SET translocation
phosphatase 2A inhibitor I2PP2A
template-activating factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204875.2 → NP_001191804.1  protein SET isoform 2

    See identical proteins and their annotated locations for NP_001191804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the shorter isoform (2; also known as isoform beta).
    Source sequence(s)
    BX005298
    Consensus CDS
    CCDS57162.1
    UniProtKB/Swiss-Prot
    Q9EQU5
    Related
    ENSMUSP00000070002.7, ENSMUST00000067996.7
    Conserved Domains (1) summary
    pfam00956
    Location:32 → 221
    NAP; Nucleosome assembly protein (NAP)

  2. NM_023871.5 → NP_076360.1  protein SET isoform 1

    See identical proteins and their annotated locations for NP_076360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1; also known as isoform alpha).
    Source sequence(s)
    BX005298
    Consensus CDS
    CCDS15866.1
    UniProtKB/Swiss-Prot
    A2BE95, Q9CY82, Q9D0A9, Q9EQU5, Q9Z181
    UniProtKB/TrEMBL
    Q3T9S3, Q5U445
    Related
    ENSMUSP00000099930.4, ENSMUST00000102866.10
    Conserved Domains (1) summary
    pfam00956
    Location:49 → 233
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29952074..29962589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQU5.1 GenPept UniProtKB/Swiss-Prot:Q9EQU5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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