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Set SET nuclear oncogene [ Mus musculus (house mouse) ]

Gene ID: 56086, updated on 8-Feb-2024

Summary

Official Symbol
Setprovided by MGI
Official Full Name
SET nuclear oncogeneprovided by MGI
Primary source
MGI:MGI:1860267
See related
Ensembl:ENSMUSG00000054766 AllianceGenome:MGI:1860267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAF-I; I-2PP2A; StF-IT-1; 2610030F17Rik; 5730420M11Rik
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; skin; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 163.2), CNS E14 (RPKM 62.3) and 28 other tissues See more
Orthologs
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Genomic context

See Set in Genome Data Viewer
Location:
2 B; 2 21.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29952074..29962589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30061996..30072577)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene protein kinase N3 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein SET
Names
SET translocation
phosphatase 2A inhibitor I2PP2A
template-activating factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204875.2NP_001191804.1  protein SET isoform 2

    See identical proteins and their annotated locations for NP_001191804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the shorter isoform (2; also known as isoform beta).
    Source sequence(s)
    BX005298
    Consensus CDS
    CCDS57162.1
    UniProtKB/Swiss-Prot
    Q9EQU5
    Related
    ENSMUSP00000070002.7, ENSMUST00000067996.7
    Conserved Domains (1) summary
    pfam00956
    Location:32221
    NAP; Nucleosome assembly protein (NAP)
  2. NM_023871.5NP_076360.1  protein SET isoform 1

    See identical proteins and their annotated locations for NP_076360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1; also known as isoform alpha).
    Source sequence(s)
    BX005298
    Consensus CDS
    CCDS15866.1
    UniProtKB/Swiss-Prot
    A2BE95, Q9CY82, Q9D0A9, Q9EQU5, Q9Z181
    UniProtKB/TrEMBL
    Q3T9S3, Q5U445
    Related
    ENSMUSP00000099930.4, ENSMUST00000102866.10
    Conserved Domains (1) summary
    pfam00956
    Location:49233
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29952074..29962589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)