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Ubqln1 ubiquilin 1 [ Mus musculus (house mouse) ]

Gene ID: 56085, updated on 8-Dec-2022

Summary

Official Symbol
Ubqln1provided by MGI
Official Full Name
ubiquilin 1provided by MGI
Primary source
MGI:MGI:1860276
See related
Ensembl:ENSMUSG00000005312 AllianceGenome:MGI:1860276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Da41; Dsk2; Plic1; Xdrp1; Plic-1; D13Ertd372e; 1110046H03Rik; 1810030E05Rik
Summary
Predicted to enable several functions, including identical protein binding activity; kinase binding activity; and polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of toll-like receptor 3 signaling pathway. Located in autophagosome. Orthologous to human UBQLN1 (ubiquilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 72.0), adrenal adult (RPKM 65.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ubqln1 in Genome Data Viewer
Location:
13 B1; 13 30.95 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58323970..58363467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58176156..58215653, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066J03 gene Neighboring gene idnK gluconokinase homolog (E. coli) Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene G kinase anchoring protein 1 Neighboring gene predicted gene, 26555

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intermediate filament binding NAS
Non-traceable Author Statement
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in aggrephagy ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ER-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquilin-1
Names
protein linking IAP with cytoskeleton 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026842.4NP_081118.4  ubiquilin-1 isoform 1

    See identical proteins and their annotated locations for NP_081118.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163038, AI425982, AK049298, AK165456
    Consensus CDS
    CCDS49281.1
    UniProtKB/Swiss-Prot
    Q8R317, Q9QZM1
    UniProtKB/TrEMBL
    Q3TN93
    Related
    ENSMUSP00000050191.6, ENSMUST00000058735.12
    Conserved Domains (4) summary
    smart00727
    Location:384416
    STI1; Heat shock chaperonin-binding motif
    cd14399
    Location:539578
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cd01808
    Location:2698
    Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl17974
    Location:204247
    STI1; STI1 domain
  2. NM_152234.2NP_689420.1  ubiquilin-1 isoform 2

    See identical proteins and their annotated locations for NP_689420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC163038, AI425982, AK048534, AK165456
    Consensus CDS
    CCDS26569.1
    UniProtKB/Swiss-Prot
    Q8R317
    UniProtKB/TrEMBL
    Q3TN93
    Related
    ENSMUSP00000075782.7, ENSMUST00000076454.8
    Conserved Domains (5) summary
    smart00727
    Location:173210
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:2898
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:2898
    UBQ; Ubiquitin homologues
    cd14399
    Location:511550
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    TIGR00601
    Location:300523
    rad23; UV excision repair protein Rad23

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58323970..58363467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)